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In the present study, a series of novel quinazoline derivatives bearing cyclopropane\u20101,1\u2010dicarboxamide moieties were designed, synthesized, and evaluated for their anticancer activity against human colorectal cancer (CRC) cell lines. The synthesized compounds were structurally characterized using 1H and 13C NMR spectroscopy and high\u2010resolution mass spectrometry. Their in vitro antiproliferative activity was assessed against HT\u201029 and COLO\u2010205 cell lines using the MTT assay, with cabozantinib serving as the reference standard. Several compounds demonstrated promising cytotoxic activity, with compound SQ14 exhibiting the most potent inhibitory effect, comparable to the standard drug. Molecular docking and molecular dynamics simulations were performed to elucidate binding interactions and stability within the active site of the target protein, revealing favorable binding orientations and key intermolecular interactions. Furthermore, in silico ADMET analysis supported the drug\u2010like nature and acceptable pharmacokinetic profiles of the lead compounds. Overall, the integrated experimental and computational findings suggest that the newly synthesized quinazoline derivatives, particularly SQ14, represent promising candidates for further development as potential anticancer agents against CRC.<\/jats:p>","DOI":"10.1002\/cbdv.202502491","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T10:39:33Z","timestamp":1772966373000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Design, Synthesis, and Biological Evaluation of Aminophenol\u2013Quinazoline\u2010Based Derivatives as Antiproliferative Agents Against Colorectal Cancer"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6995-2806","authenticated-orcid":false,"given":"Sachin A.","family":"Dhawale","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Chemistry Y.B. 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