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In this study, magnesium oxide nanoparticles (MgO NPs) were synthesized\n                    <jats:italic>via<\/jats:italic>\n                    a green approach using\n                    <jats:italic>Spirulina platensis<\/jats:italic>\n                    extract. X\u2010ray diffraction, Fourier\u2010transform infrared spectroscopy, and scanning electron microscopy confirmed their crystalline structure, uniform spherical morphology, and an average size of 20.19\u00a0nm. The NPs exhibited notable antioxidant activity (IC\n                    <jats:sub>50<\/jats:sub>\n                    = 82.75\u00a0\u00b5g\/mL, DPPH assay) and strong reducing power in the ferric reducing antioxidant power assay. Antimicrobial testing showed broad\u2010spectrum activity against Gram\u2010negative and Gram\u2010positive bacteria as well as\n                    <jats:italic>Candida albicans<\/jats:italic>\n                    , with a low minimum inhibitory concentration value (7.81\u00a0\u00b5g\/mL). Moreover, MgO NPs disrupted preformed biofilms with 77.6% inhibition. Anticancer activity evaluation on HT\u201029 colorectal adenocarcinoma cells revealed dose\u2010dependent cytotoxicity at 24\u00a0h, while non\u2010cancerous cells retained\u00a0high biocompatibility. Collectively, these findings highlight the potential of green\u2010synthesized MgO NPs as eco\u2010friendly multifunctional agents against biofilm\u2010associated infections and cancer.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202502550","type":"journal-article","created":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T16:26:38Z","timestamp":1764951998000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Exploiting the Biogenic Potential of\n                    <i>Spirulina platensis<\/i>\n                    for the Sustainable Synthesis of Multifunctional and Bioactive Magnesium Oxide Nanoparticles"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-7382-3790","authenticated-orcid":false,"given":"Amina","family":"Bourouba","sequence":"first","affiliation":[{"name":"Laboratory of Cell Toxicology Badji Mokhtar\u2010Annaba University, 12, P.O. 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