{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T18:58:45Z","timestamp":1790017125471,"version":"4.0.1"},"reference-count":45,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T00:00:00Z","timestamp":1768003200000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Hericium erinaceus<\/jats:italic>\n                    (Bull.) Pers., an edible and medicinal mushroom, has garnered significant scientific interest due to its rich array of bioactive compounds. Extensive research has highlighted the pharmacological properties of its constituents, including neuroprotective, neurotrophic, immunomodulatory, and anticancer activities. Among interesting bioactive secondary metabolites in\n                    <jats:italic>H. erinaceus<\/jats:italic>\n                    , hericenones\u2014a structurally unique class of geranyl\u2010resorcinol derivatives\u2014have emerged as particularly promising pharmacological agents. This review comprehensively covers the 24 known natural hericenones and one semisynthetic derivative, detailing their structural elucidation with a focus on characteristic NMR spectroscopy to provide a systematic identification guide. Furthermore, the review discusses their biosynthesis, isolation methodologies, and beneficial biological properties. These include the stimulation of nerve growth factor (NGF), as well as anti\u2010inflammatory, antioxidant, anticancer, antidiabetic, antiplatelet, and anti\u2010obesity. By integrating chemical and pharmacological perspectives, this work underscores the promise of hericenones as lead compounds for the development of novel therapeutics.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202502560","type":"journal-article","created":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T19:06:39Z","timestamp":1768071999000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Hericenones From\n                    <i>Hericium erinaceus<\/i>\n                    (Bull.) Pers.: A Scoping Review of Structural Diversity and Health Benefits"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2827-7621","authenticated-orcid":false,"given":"Ahmed","family":"Othman","sequence":"first","affiliation":[{"name":"Department of Pharmacognosy and Medicinal Plants Faculty of Pharmacy, Al\u2010Azhar University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2552-4567","authenticated-orcid":false,"given":"Yhiya","family":"Amen","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy Faculty of Pharmacy, Mansoura University  Mansoura Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5960-1503","authenticated-orcid":false,"given":"Kuniyoshi","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Department of Agro\u2010Environmental Sciences Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University  Fukuoka Japan"},{"name":"Kyushu University Institute of Asian and Oceanic Studies  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,10]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/ja.2010.112"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jnatprod.4c01018"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/ACS.JOC.0C02681"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1875\u20105364(24)60590\u2010X"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0040\u20104039(00)94558\u20101"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1248\/BPB.31.1727"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.2220\/biomedres.40.125"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2015.10.016"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0040\u20104039(91)80039\u20109"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/MOLECULES27072157"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1055\/A\u20101944\u20109623"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/MOLECULES29235576\/S1"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.FITOTE.2016.04.010"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.PHYTOL.2019.04.017"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0040\u20104039(92)88100\u2010J"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/JO500795Z"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.BMC.2008.09.044"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/14786419.2023.2169687"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.FOODCHEM.2014.08.078"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1875\u20105364(12)60072\u20107"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/ja.2012.65"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9FO01672D"},{"key":"e_1_2_11_24_1","unstructured":"Hunan Xinhui Pharmaceutical Co. Ltd. Hericenone M and Hericenone N CN 108440380 A (2018) https:\/\/patents.google.com\/patent\/CN108440380A\/zh."},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/0031\u20109422(92)80127\u2010Z"},{"key":"e_1_2_11_26_1","first-page":"96","article-title":"Chemical Constituents of the Fungus Hericium erinaceus SH1","volume":"46","author":"Huong L. M.","year":"2008","journal-title":"Journal of Chemistry"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.3390\/MOLECULES24193511"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1039\/C4FO00452C"},{"key":"e_1_2_11_29_1","unstructured":"P. E.Stamets Compositions and Methods for Enhancing Neuroregeneration and Cognition by Combining Mushroom Extracts Containing Active Ingredients Psilocin or Psilocybin With Erinacines or Hericenones Enhanced With Niacin US 2018 \/0021326 A1 (2018)."},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.3390\/NU11040715"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.3390\/IJMS22126379"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.3390\/MOLECULES28114549\/S1"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.3c10459"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.3109\/08923973.2014.947036"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JEP.2016.02.038"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.BBRC.2024.150077"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1051\/e3sconf\/202235502016"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.PHYMED.2010.05.004"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/S11418\u2010017\u20101075\u20108"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JEP.2020.113197"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/S41598\u2010017\u201011457\u2010W"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1055\/A\u20101146\u20108369"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.TET.2011.11.068"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1021\/np50107a006"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.3109\/14756366.2014.995181"},{"key":"e_1_2_11_46_1","first-page":"39","article-title":"Constituents of Mushrooms. XXV. Structures of New Aromatic Compounds From the Fruiting Bodies of Hericium erinaceum (Bull.: Fr.) Pers","volume":"52","author":"Yaoita Y.","year":"2005","journal-title":"Journal of Tohoku Pharmaceutical University"}],"container-title":["Chemistry &amp; Biodiversity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbdv.202502560","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cbdv.202502560","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbdv.202502560","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T07:53:14Z","timestamp":1785484394000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cbdv.202502560"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":45,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1002\/cbdv.202502560"],"URL":"https:\/\/doi.org\/10.1002\/cbdv.202502560","archive":["Portico"],"relation":{},"ISSN":["1612-1872","1612-1880"],"issn-type":[{"value":"1612-1872","type":"print"},{"value":"1612-1880","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2025-08-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e02560"}}