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Taxifolin (TAX), a flavonoid with diverse pharmacological properties, has received limited attention in dermatological applications. In this study, TAX significantly alleviated MCA\u2010induced damage in human epidermal keratinocytes (HaCaT cells) was demonstrated. MTT assays revealed that 12.5, 25, and 50\u00a0\u00b5M concentrations of TAX effectively reversed the MCA\u2010induced decrease in HaCaT cells. Furthermore, immunofluorescence and flow cytometry analyses showed that TAX markedly reduced reactive oxygen species (ROS) levels and apoptosis induced by MCA. In addition, TAX attenuated ROS\u2010mediated DNA damage caused by MCA. Given that DNA damage can activate the cytosolic DNA sensor cyclic GMP\u2013AMP synthase (cGAS), the involvement of the cGAS\u2013stimulator of interferon genes (STING) pathway was further examined. The results showed that TAX inhibited the activation of cGAS\u2013STING pathway, thereby preventing downstream NF\u2010\u03baB activation and the release of proinflammatory cytokines. These findings demonstrate the protective effect of TAX against MCA\u2010induced skin damage and highlight its potential as a candidate for future dermatological applications.<\/jats:p>","DOI":"10.1002\/cbdv.202502583","type":"journal-article","created":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T16:44:33Z","timestamp":1760114673000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Protective Effect of Taxifolin Against Monochloroacetic Acid\u2010Induced Skin Damage via Inhibition of the cGAS\/STING\/NF\u2010\u03baB Pathway"],"prefix":"10.1002","volume":"22","author":[{"given":"Hui","family":"Yu","sequence":"first","affiliation":[{"name":"School of Life Science Liaoning University  Shenyang People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Le","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Life Science Liaoning University  Shenyang 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