{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T08:01:43Z","timestamp":1785484903933,"version":"3.56.0"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T00:00:00Z","timestamp":1767830400000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Proinflammatory cytokine interleukin (IL)\u20101\u03b2 is a key mediator of the inflammatory response in atherosclerosis. Targeting IL\u20101\u03b2 represents a new approach for the anti\u2010inflammatory therapy of cardiovascular diseases. Based on our previous data demonstrating that cardioprotective 6\u2010piperazinyl purines can effectively inhibit IL\u20101\u03b2 release in vascular cells, in this study, we present the synthesis of a next generation of purine analogues bearing either a furoxan moiety as a nitric oxide (NO) donor, or a (methylsulfonyl)thio group, a benzothioamide, or a 5\u2010phenyl\u20103H\u20101,2\u2010dithiole\u20103\u2010thione as putative hydrogen sulfide (H\n                    <jats:sub>2<\/jats:sub>\n                    S) donor moieties. NO and H\n                    <jats:sub>2<\/jats:sub>\n                    S are gaseous signaling molecules that can reduce vascular inflammation. The new purine analogues were evaluated for their anti\u2010inflammatory activity by assessing their inhibitory effect on the secretion of lipopolysaccharide (LPS)\u2010induced IL\u20101\u03b2 in human aortic smooth muscle cells (HAoSMCs). Our initial findings revealed that compounds bearing a [methylsulfonyl)thio]propanoyl or [methylsulfonyl)thio]hexanoyl group (compounds\n                    <jats:bold>MK175<\/jats:bold>\n                    and\n                    <jats:bold>MK169<\/jats:bold>\n                    , respectively) could effectively inhibit LPS\u2010induced IL\u20101\u03b2 release in HAoSMCs.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202502588","type":"journal-article","created":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T11:52:32Z","timestamp":1767873152000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Design and Synthesis of Novel Purine Analogues as Potential IL\u20101\u03b2 Inhibitors Targeting Vascular Inflammation"],"prefix":"10.1002","volume":"23","author":[{"given":"Dimitra T.","family":"Pournara","sequence":"first","affiliation":[{"name":"Institute of Chemical Biology National Hellenic Research Foundation  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theano","family":"Fotopoulou","sequence":"additional","affiliation":[{"name":"Institute of Chemical Biology National Hellenic Research Foundation  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geena","family":"Paramel","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health Cardiovascular Research Centre, \u00d6rebro University  \u00d6rebro Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madelene","family":"Lindkvist","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health Cardiovascular Research Centre, \u00d6rebro University  \u00d6rebro Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magnus","family":"Greneg\u00e5rd","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health Cardiovascular Research Centre, \u00d6rebro University  \u00d6rebro Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Frans\u00e9n","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health Cardiovascular Research Centre, \u00d6rebro University  \u00d6rebro Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9351-8279","authenticated-orcid":false,"given":"Maria","family":"Koufaki","sequence":"additional","affiliation":[{"name":"Institute of Chemical Biology National Hellenic Research Foundation  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,8]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232112906"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538\u20107836.2009.03416.x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1707914"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2015.04.014"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.115.003031"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2022.927061"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1202479"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2013.6"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr000040l"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2022.175128"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00395\u2010015\u20100510\u20109"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2425"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1517\/17460441.2016.1122590"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.934231"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M117.806869"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2012.07.037"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.202000303"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476\u20105381.2011.01704.x"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2012.10.019"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tetlet.2017.05.010"}],"container-title":["Chemistry &amp; Biodiversity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbdv.202502588","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cbdv.202502588","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbdv.202502588","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T07:54:09Z","timestamp":1785484449000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cbdv.202502588"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1002\/cbdv.202502588"],"URL":"https:\/\/doi.org\/10.1002\/cbdv.202502588","archive":["Portico"],"relation":{},"ISSN":["1612-1872","1612-1880"],"issn-type":[{"value":"1612-1872","type":"print"},{"value":"1612-1880","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2025-08-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e02588"}}