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Phenolics, flavonoids, and tannins were quantified spectrophotometrically, individual metabolites profiled by HPLC\/UV\u2013ESI\u2013MS, and volatile components by GC\u2013MS. Antioxidant capacity (DPPH, FRAP, TAC), antimicrobial activity (MIC\/MBC or MFC against 29 bacteria and 8 fungi), and anticoagulant effects (prothrombin time [PT] and activated partial thromboplastin time [aPTT]) were assessed. Molecular docking targeted \u03b2\u2010lactamases (OXA\u201010), thrombin, and myeloperoxidase. The decoction (E1) showed the highest phenolic (56.8\u00a0mg GAE\/g) and flavonoid (22.8\u00a0mg QE\/g) contents and superior radical\u2010scavenging activity (DPPH IC\n                    <jats:sub>50<\/jats:sub>\n                    \u00a0=\u00a0228.8\u00a0\u00b5g\/mL). The EO was dominated by (\n                    <jats:italic>E<\/jats:italic>\n                    )\u2010anethole (79.7%) and fenchone (7.7%). The aqueous extract is rich in phenolic acids and flavonoids (quercetin\u20103\u2010glucuronide 12.13%, chlorogenic acid 10.63%), typifying a caffeoylquinic acid\u2013glucuronidated flavonol chemotype. Antimicrobial testing showed that the aqueous extract stopped\n                    <jats:italic>Acinetobacter baumannii<\/jats:italic>\n                    from growing (MIC\u00a0=\u00a0600\u00a0\u00b5g\/mL) and the EO stopped\n                    <jats:italic>Candida parapsilosis<\/jats:italic>\n                    from growing (MIC\u00a0=\u00a01200\u00a0\u00b5g\/mL). E1 extended the aPTT to 73.7\u00a0s compared to 34.6\u00a0s in the control group, indicating disruption of the intrinsic coagulation pathway, whereas PT exhibited minimal alteration. Docking studies revealed that quercetin\u20103\u2010glucuronide demonstrates significant binding affinity to \u03b2\u2010lactamase OXA\u201010 (\u22126.4\u00a0kcal\/mol) and thrombin (\u22127.4\u00a0kcal\/mol), thereby substantiating its proposed roles in antibacterial and anticoagulant activities. In general,\n                    <jats:italic>F. vulgare<\/jats:italic>\n                    aqueous extracts and EO have antioxidant, antimicrobial, and anticoagulant properties that work well together. Phenolic glycosides and (\n                    <jats:italic>E<\/jats:italic>\n                    )\u2010anethole are the main ingredients that make this happen. These results bolster translational opportunities for the development of cardiovascular, antimicrobial, and nutraceutical adjuncts, while emphasising the necessity for in vivo validation, bioavailability investigations, and long\u2010term safety evaluations.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202502590","type":"journal-article","created":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T17:50:40Z","timestamp":1769190640000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Comprehensive In Vitro and In Silico Evaluation of\n                    <i>Foeniculum vulgare<\/i>\n                    Seeds: Phytochemicals, Antioxidant Power, Antimicrobial Action, and Anticoagulant Activity"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9036-5289","authenticated-orcid":false,"given":"Aziz","family":"Drioiche","sequence":"first","affiliation":[{"name":"Higher Institute of Nursing Professions and Health Techniques of Fez, Regional Health Directorate Fez\u2010Meknes, EL Ghassani Hospital  Fez Morocco"},{"name":"Research Team of Chemistry of Bioactive Molecules and the Environment, Laboratory of Innovative Materials and Biotechnology of Natural Resources, Faculty of Sciences Moulay Isma\u00efl University  Meknes Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omkulthom","family":"Al kamaly","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences College of Pharmacy Princess Nourah Bint Abdulrahman. 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