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FTIR confirmed the presence of sulfate groups, while GC\u2010MS identified diverse sugar components. Both polysaccharides showed strong antioxidant activity, with DPPH and ABTS radical scavenging rates exceeding 50% at the highest concentrations. In a rat model of gastric ulceration, PSUT and PSUM significantly reduced inflammation and lymphocytic infiltration and lowered the activities of 5\u2010lipoxygenase and myeloperoxidase. Treatment also produced clear antioxidant effects, decreasing hydrogen peroxide by 48% and 61% and reducing TBARS by 65% and 71%, respectively. In addition, both polysaccharides inhibited gastric H\n                    <jats:sup>+<\/jats:sup>\n                    \/K\n                    <jats:sup>+<\/jats:sup>\n                    \u2010ATPase and pepsin, contributing to notable anti\u2010acidic effects and improved protection of the gastric mucosa. Mucin levels increased by 82% and 100%, while gastric mucus content rose by 32% and 71% for PSUT and PSUM. Overall, PSUM displayed stronger in vivo anti\u2010inflammatory and gastroprotective activities, whereas PSUT showed slightly higher in vitro antioxidant capacity. These findings confirm that the geographic origin of\n                    <jats:italic>U. lactuca<\/jats:italic>\n                    influences the structural features of its polysaccharides and their biological effects. Although based on a single animal model and dose, this work offers a solid basis for future mechanistic and clinical investigations.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202502636","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T17:00:03Z","timestamp":1772989203000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparative Study of Sulfated Polysaccharides From\n                    <i>Ulva Lactuca<\/i>\n                    Grown in Tunisia and Morocco:\n                    <i>in Vitro<\/i>\n                    Antioxidant Activity and\n                    <i>in Vivo<\/i>\n                    Anti\u2010Inflammatory and Anti\u2010Ulcer Effects"],"prefix":"10.1002","volume":"23","author":[{"given":"Nourhene","family":"Kharrat","sequence":"first","affiliation":[{"name":"Faculty of Sciences of Sfax Laboratory of Organic Chemistry LR17\u2010ES08 (Natural Substances Team) University of Sfax  Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasmine","family":"Touhamia","sequence":"additional","affiliation":[{"name":"Department of Biology Faculty of Sciences\u2013 Ain Chock Health and Environment Laboratory University Hassan II  Casablanca Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rihab Ben","family":"Abdallah kolsi","sequence":"additional","affiliation":[{"name":"Faculty of Sciences of Sfax Laboratory of Plant Biotechnology  Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khaled","family":"Hamden","sequence":"additional","affiliation":[{"name":"Laboratory of Bioresources: Integrative Biology and Exploiting Higher Institute of Biotechnology of Monastir University of Monastir  Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafik Ben","family":"Said","sequence":"additional","affiliation":[{"name":"Laboratory of Blue Biotechnology and Aquatic Bioproducts\u2010B3Aqua National Institute of Marine Sciences and Technologies (INSTM)  Salammb\u00f4 Tunis Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Touria Ould Bel","family":"Lahcen","sequence":"additional","affiliation":[{"name":"Department of Biology Faculty of Sciences\u2013 Ain Chock Health and Environment Laboratory University Hassan II  Casablanca Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hichem Ben","family":"Salah","sequence":"additional","affiliation":[{"name":"Faculty of Sciences of Sfax Laboratory of Organic Chemistry LR17\u2010ES08 (Natural Substances Team) University of Sfax  Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0362-492X","authenticated-orcid":false,"given":"Noureddine","family":"Allouche","sequence":"additional","affiliation":[{"name":"Faculty of Sciences of Sfax Laboratory of Organic Chemistry LR17\u2010ES08 (Natural Substances Team) University of Sfax  Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,3,2]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.202401728"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.202570401"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0100\u2010879X2007000100002"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.2174\/1381612043452758"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules13081671"},{"key":"e_1_2_9_7_1","first-page":"1639","article-title":"Structural Analysis of Fucoidans","volume":"3","author":"Bilan M. 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