{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T06:03:18Z","timestamp":1791612198997,"version":"4.3.4"},"reference-count":56,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T00:00:00Z","timestamp":1764720000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T00:00:00Z","timestamp":1764720000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    In this study,\n                    <jats:italic>Carthamus tinctorius<\/jats:italic>\n                    was separated into distinct parts (flower [F], stem\u2010leaf [SL], and root [R]) and subjected to two different extraction protocols (water\u2010ethyl acetate [WEA] and methanol\u2010chloroform [MC]). The chemical profiles of the extracts were comprehensively characterized using HPLC\u2013TOF\/MS. Analytical results identified\n                    <jats:italic>p<\/jats:italic>\n                    \u2010coumaric acid as the predominant compound in the WEA, whereas syringic acid was found to be the major constituent in the MC extracts. The antiproliferative activities of the extracts were assessed in the xCELLigence real\u2010time cell analysis (RTCA) SP system on human prostate cancer (PC3) and rat glioma (C6) cell lines. RWEA showed the strongest antiproliferative activity against PC3 cells (IC\n                    <jats:sub>50<\/jats:sub>\n                    \u00a0=\u00a021.044\u00a0\u00b5g\/mL), whereas SLWEA was most effective on C6 cells (IC\n                    <jats:sub>50<\/jats:sub>\n                    \u00a0=\u00a012.759\u00a0\u00b5g\/mL). This study offers novel and significant insights into the bioactive constituents of\n                    <jats:italic>C. tinctorius<\/jats:italic>\n                    by presenting, for the first time in real\u2010time analyses, compelling evidence of its potent antiproliferative activity against PC3 and C6 cell lines.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202502681","type":"journal-article","created":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T20:13:19Z","timestamp":1764792799000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Real\u2010Time Antiproliferative Activity of\n                    <i>Carthamus tinctorius<\/i>\n                    L. (Safflower) Against PC3 and C6 Cell Lines: A Correlative Chemical Profile Assessment"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0387-1819","authenticated-orcid":false,"given":"Muhammed","family":"Altun","sequence":"first","affiliation":[{"name":"Eldivan Vocational School of Health Services, Department of Medical Services and Techniques \u00c7ank\u0131r\u0131 Karatekin University  \u00c7ank\u0131r\u0131 T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali R\u0131za","family":"T\u00fcfek\u00e7i","sequence":"additional","affiliation":[{"name":"Faculty of Sciences, Department of Chemistry \u00c7ank\u0131r\u0131 Karatekin University  \u00c7ank\u0131r\u0131 T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melike","family":"Demirda\u011f Ya\u011fci","sequence":"additional","affiliation":[{"name":"Faculty of Sciences, Department of Chemistry \u00c7ank\u0131r\u0131 Karatekin University  \u00c7ank\u0131r\u0131 T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,3]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1590\/0001-3765201920190105"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.afres.2025.101275"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2022.113054"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgeb.2025.100553"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu8080515"},{"key":"e_1_2_9_7_1","doi-asserted-by":"crossref","first-page":"17","DOI":"10.24925\/turjaf.v1i1.17-22.26","article-title":"\u0130\u00e7 Anadolu B\u00f6lgesinde Ya\u011f Bitkilerinin mevcut Durumu, Sorunlar\u0131 Ve \u00c7\u00f6z\u00fcm \u00d6nerileri","volume":"1","author":"\u00c7al\u0131\u015fkan S.","year":"2013","journal-title":"Turkish Journal of Agriculture\u2010Food Science and Technology"},{"key":"e_1_2_9_8_1","first-page":"30","article-title":"Yabani Aspir'in (Carthamus persicus Wild) In Vitro \u00c7o\u011falt\u0131m\u0131nda Farkl\u0131 BAP\u2010NAA Kombinasyonlar\u0131n\u0131n Etkisi","volume":"24","author":"\u00d6zdemir F. 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