{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T07:00:01Z","timestamp":1775890801397,"version":"3.50.1"},"reference-count":88,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T00:00:00Z","timestamp":1770595200000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001412","name":"Council of Scientific and Industrial Research, India","doi-asserted-by":"publisher","award":["27\/0393\/23\/EMR\u2010II"],"award-info":[{"award-number":["27\/0393\/23\/EMR\u2010II"]}],"id":[{"id":"10.13039\/501100001412","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>In the current study, we have designed three hitherto unreported, aldimine\u2010based zinc complexes, used as precursors to prepare the corresponding zinc oxide nanomaterials. The complexes are further assessed for binding propensity with BSA and human serum albumin (HSA), the homologous proteins. The interactions with plasma proteins indicate the drug\u2010like behaviour of the complexes and play a significant role in drug design and pharmacology research. Both proteins possess typical physicochemical properties and functions, acting as drug carriers in plasma. UV absorption titration and fluorescence quenching studies have been used to investigate the interaction of zinc complexes with both proteins. From the results, it has been observed that the ZnHL3 complex shows higher binding constants than the other complexes. Drug loading is a promising approach for developing amorphous pharmaceuticals that are highly stable and have enhanced bioavailability, solubility, and dissolution rates. Hence, we have assessed the relative curcumin loading abilities of complex\/nanomaterial\u2010coated BSA.<\/jats:p>","DOI":"10.1002\/cbdv.202502689","type":"journal-article","created":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T20:22:37Z","timestamp":1770668557000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Zinc Complexes as Precursors for Zinc Oxide and Protein Interaction Studies for Drug\u2010Loading Applications"],"prefix":"10.1002","volume":"23","author":[{"given":"Amudha","family":"Sekar","sequence":"first","affiliation":[{"name":"Department of Chemistry School of Advanced Sciences Vellore Institute of Technology  Vellore India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7936-1850","authenticated-orcid":false,"given":"Angappan","family":"Sheela","sequence":"additional","affiliation":[{"name":"Department of Chemistry School of Advanced Sciences Vellore Institute of Technology  Vellore India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,9]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2025.142340"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2025.141722"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphotobiol.2014.04.013Get"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2020.129356"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2021.130112"},{"key":"e_1_2_9_7_1","first-page":"571","article-title":"Preparation and Characterization of ZnO Nanoparticles via Thermal Decomposition From Zinc(II) Schiff Base Complex as a New Precursor","volume":"3","author":"Khalaji A. D.","year":"2019","journal-title":"Chemical Methodologies"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molliq.2021.117045"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2024.137495"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2023.126856"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2016.10.009"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.22036\/ncr.2017.01.011"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10895\u2010016\u20102000\u20103"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/07391102.2021.1947382"},{"key":"e_1_2_9_15_1","first-page":"643","article-title":"Synthesis of Nanoparticles by Using Schiff Base Cu(II) and Zn(II) Complexes as a Precursor and Its Antibacterial Studies","volume":"8","author":"George N.","year":"2019","journal-title":"International Journal of Science and Research"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ica.2020.120142"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/23080477.2017.1328910"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1080\/24701556.2020.1814337"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1088\/2632\u2010959X\/abc813"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/281461"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.materresbull.2016.02.010"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.22036\/ncr.2017.01.011"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10895\u2010016\u20102000\u20103"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultsonch.2011.05.007"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2017.02.026"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpcs.2018.02.008"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2013.09.021"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2018.04.043"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1080\/07391102.2018.1512899"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9NJ02377A"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9DT04636D"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molliq.2021.117045"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9DT04636D"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0NJ03844J"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1039\/D3RA06270H"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/aoc.4680"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.6b04933"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2025.125889"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10924\u2010022\u201002401\u20109"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.202500051"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28124777"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/slct.202400618"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.inoche.2024.112246"},{"key":"e_1_2_9_44_1","first-page":"188","article-title":"Preparation of Schiff Base Zinc Metal Complex (DMAPIMP) 2 Zn and Development of HPLC Chromatographic Method for Its Analysis","volume":"3","author":"Yamgar R.","year":"2011","journal-title":"Journal of Chemistry"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2024.141076"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2021.109714"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2017.08.040"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010022\u201014630\u2010y"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1134\/S1068162022010058"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.poly.2023.116736"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2017.08.040"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40995\u2010024\u201001641"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.langmuir.2c00671"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jlumin.2012.10.044"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.saa.2012.05.009"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.saa.2012.02.060"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jlumin.2011.10.023"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.saa.2010.06.010"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2011.02.012"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1021\/ic202141g"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1039\/C1DT10767D"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2013.12.019"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpha.2016.10.001"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2017.04.030"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphotobiol.2013.05.007"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1080\/07391102.2023.2196696"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2022.133939"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2015.04.033"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ica.2017.05.035"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00775\u2010017\u20101505\u20109"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2015.04.033"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ica.2015.03.016"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matchemphys.2024.129485"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12668\u2010019\u201000698\u2010w"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10854\u2010019\u201002612\u20102"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jssc.2019.05.001"},{"key":"e_1_2_9_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rechem.2023.101026"},{"key":"e_1_2_9_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rinp.2013.01.005"},{"key":"e_1_2_9_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apcata.2014.10"},{"key":"e_1_2_9_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.inoche.2023.110760"},{"key":"e_1_2_9_81_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10876\u2010014\u201008"},{"key":"e_1_2_9_82_1","doi-asserted-by":"publisher","DOI":"10.17344\/acsi.2018.4213"},{"key":"e_1_2_9_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nanoso.2025.101529"},{"key":"e_1_2_9_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hybadv.2024.100342"},{"key":"e_1_2_9_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2018.04.043"},{"key":"e_1_2_9_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hybadv.2024.100342"},{"key":"e_1_2_9_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gerr.2024.100073"},{"key":"e_1_2_9_88_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10924\u2010022\u201002401\u20109"},{"key":"e_1_2_9_89_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.202500051"}],"container-title":["Chemistry &amp; Biodiversity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbdv.202502689","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cbdv.202502689","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbdv.202502689","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T06:29:57Z","timestamp":1775888997000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cbdv.202502689"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":88,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1002\/cbdv.202502689"],"URL":"https:\/\/doi.org\/10.1002\/cbdv.202502689","archive":["Portico"],"relation":{},"ISSN":["1612-1872","1612-1880"],"issn-type":[{"value":"1612-1872","type":"print"},{"value":"1612-1880","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"2025-08-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e02689"}}