{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T16:04:14Z","timestamp":1785341054695,"version":"3.55.0"},"reference-count":40,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T00:00:00Z","timestamp":1776729600000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    In present study, non\u2010volatile cytotoxic phytoconstituents of\n                    <jats:italic>Vetiveria zizanioides<\/jats:italic>\n                    roots have been explored. The root extract afforded a new\n                    <jats:italic>nor<\/jats:italic>\n                    \u2010sesquiterpene (an azulene derivative)\n                    <jats:bold>(1)<\/jats:bold>\n                    , phenolic acid\n                    <jats:bold>(2)<\/jats:bold>\n                    , flavonoid\n                    <jats:bold>(3)<\/jats:bold>\n                    , flavonoid glycosides\n                    <jats:bold>(4<\/jats:bold>\n                    ,\n                    <jats:bold>5)<\/jats:bold>\n                    and sterol glycoside\n                    <jats:bold>(6)<\/jats:bold>\n                    . The crude extract, solvent\u2010partitioned fractions, and isolated compounds (\n                    <jats:bold>1<\/jats:bold>\n                    ,\n                    <jats:bold>3<\/jats:bold>\n                    ,\n                    <jats:bold>4<\/jats:bold>\n                    ,\n                    <jats:bold>5<\/jats:bold>\n                    , and\n                    <jats:bold>6<\/jats:bold>\n                    ) were screened for in vitro cytotoxic activity against the HCT\u2010116 (human colon cancer) cell line. In parallel, total phenolic content (TPC), total flavonoid content (TFC), antioxidant activity (DPPH and ABTS assays), and HPLC profiling gave comprehensive insight into the phytochemical profile. Among all fractions,\n                    <jats:italic>n<\/jats:italic>\n                    \u2010butanol fraction exhibited the highest levels of phenolics, flavonoids, and antioxidant activity while\n                    <jats:italic>n<\/jats:italic>\n                    \u2010hexane fraction showed highest cytotoxic potential (IC\n                    <jats:sub>50<\/jats:sub>\n                    = 105.23\u00a0\u00b5g\/mL). Compound\n                    <jats:bold>5<\/jats:bold>\n                    showed the most potent cytotoxic effect (IC\n                    <jats:sub>50<\/jats:sub>\n                    = 10.29\u00a0\u00b5g\/mL), while compounds\n                    <jats:bold>1<\/jats:bold>\n                    (45.28\u00a0\u00b5g\/mL),\n                    <jats:bold>3<\/jats:bold>\n                    (20.22\u00a0\u00b5g\/mL),\n                    <jats:bold>4<\/jats:bold>\n                    (48.95\u00a0\u00b5g\/mL), and\n                    <jats:bold>6<\/jats:bold>\n                    (36.02\u00a0\u00b5g\/mL) also showed significant activity. Further, Compounds\n                    <jats:bold>1<\/jats:bold>\n                    ,\n                    <jats:bold>3<\/jats:bold>\n                    ,\n                    <jats:bold>4<\/jats:bold>\n                    ,\n                    <jats:bold>5<\/jats:bold>\n                    , and\n                    <jats:bold>6<\/jats:bold>\n                    showed no cytotoxicity toward the RAW 264.7 cell line. The study highlights the cytotoxic potential of\n                    <jats:italic>V. zizanioides<\/jats:italic>\n                    roots and its non\u2010volatile constituents, with compound\n                    <jats:bold>5<\/jats:bold>\n                    showing the highest activity. Compounds\n                    <jats:bold>1<\/jats:bold>\n                    ,\n                    <jats:bold>4<\/jats:bold>\n                    , and\n                    <jats:bold>6<\/jats:bold>\n                    are reported for the first time from its root.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202502702","type":"journal-article","created":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T12:06:51Z","timestamp":1776773211000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A New\n                    <i>nor<\/i>\n                    \u2010Sesquiterpene, Khusynoic Acid and Other Non\u2010Volatile Anticancer Compounds From\n                    <i>Vetiveria zizanioides<\/i>\n                    Root"],"prefix":"10.1002","volume":"23","author":[{"given":"M.","family":"Soni","sequence":"first","affiliation":[{"name":"Department of Natural Products National Institute of Pharmaceutical Education and Research  S.A.S. Nagar Punjab India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I. P.","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Natural Products National Institute of Pharmaceutical Education and Research  S.A.S. Nagar Punjab India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Bose","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Technology Biotechnology National Institute of Pharmaceutical Education and Research  S.A.S. Nagar Punjab India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2506-5364","authenticated-orcid":false,"given":"U. R.","family":"Lal","sequence":"additional","affiliation":[{"name":"Department of Natural Products National Institute of Pharmaceutical Education and Research  S.A.S. Nagar Punjab India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,21]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules24101897"},{"key":"e_1_2_9_3_1","unstructured":"N.Ch\u014dmchalao \u201cThe Utilization of Vetiver as Medicinal and Aromatic Plants: With Special Reference to Thailand. Pacific Rim Vetiver Network. 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