{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T07:03:27Z","timestamp":1775891007870,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T00:00:00Z","timestamp":1763683200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T00:00:00Z","timestamp":1763683200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100018602","name":"Guangxi Innovation-Driven Development Project","doi-asserted-by":"publisher","award":["GuiKe AA18242040"],"award-info":[{"award-number":["GuiKe AA18242040"]}],"id":[{"id":"10.13039\/501100018602","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Harmful insects cause substantial losses in agricultural production. While chemical pesticides effectively suppress pests, they also exacerbate issues such as increased pest resistance and environmental pollution. To address these challenges, this study employed matrine as a lead compound and via a molecular hybridization approach, conjugated it with oxime\u2010based structure. This approach synthesized 32 previously unreported matrine\u2010oxime derivatives, whose insecticidal activities were systematically evaluated against key agricultural pests. The contact and stomach toxicity assays revealed that most compounds displayed promising insecticidal activity against red imported fire ant, cowpea thrips, and melon fly. Notably, compound B1 achieved a stomach toxicity mortality rate of 87.69% against fire ants at concentrations \u2265\u00a02\u00a0mg\/mL, outperforming the positive control abamectin. Structure\u2013activity relationship (SAR) analysis demonstrated that oxime ether derivatives exhibited superior insecticidal activity compared to oxime esters, with electron\u2010withdrawing groups significantly enhancing potency. Moreover, the position of substituents markedly influenced efficacy. Molecular docking studies further elucidated the plausible binding modes of the derivatives with target proteins. These findings suggest that matrine\u2010oxime ether hybrids represent a class of highly effective and eco\u2010friendly insecticide candidates.<\/jats:p>","DOI":"10.1002\/cbdv.202502704","type":"journal-article","created":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T19:59:46Z","timestamp":1763755186000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Design, Synthesis, and Insecticidal Activity of 14\u2010Oxime Matrine Derivatives"],"prefix":"10.1002","volume":"23","author":[{"given":"Gan","family":"Qiu","sequence":"first","affiliation":[{"name":"School of Chemistry and Chemical Engineering Guangxi University  Nanning China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuyan","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Chemistry and Chemical Engineering Guangxi University  Nanning China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Long","sequence":"additional","affiliation":[{"name":"School of Chemistry and Chemical Engineering Guangxi University  Nanning China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jamal A. 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