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All compounds were evaluated for antifouling activity against\n                    <jats:italic>Balanus amphitrite<\/jats:italic>\n                    cyprid larval settlement. Aglycone of yadanzioside D (\n                    <jats:bold>6<\/jats:bold>\n                    ) not only exhibits potent anti\u2010settlement activity but also demonstrates low toxicity, with an EC\n                    <jats:sub>50<\/jats:sub>\n                    of 1.06\u00a0\u00b5g\/mL and an LC\n                    <jats:sub>50<\/jats:sub>\n                    \/EC\n                    <jats:sub>50<\/jats:sub>\n                    ratio of 20.68 (&gt;15, indicating low toxicity), outperforming the positive control SeaNine 211. Further resuscitation and zebrafish embryo assays also confirmed its low toxicity, highlighting its potential as a promising antifouling candidate.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202502710","type":"journal-article","created":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T19:00:13Z","timestamp":1771268413000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Discovery of Quassinoids and Indole Alkaloids With Antifouling Activity Against Barnacle Settlement From the Seeds of\n                    <i>Brucea javanica<\/i>"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-0897-0073","authenticated-orcid":false,"given":"Wang","family":"Jiang","sequence":"first","affiliation":[{"name":"National Demonstration Center For Experimental Plant Science Education College of Agriculture Guangxi University  Nanning P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tongtong","family":"Luan","sequence":"additional","affiliation":[{"name":"Institute of Marine Drugs Guangxi University of Chinese Medicine  Nanning P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinya","family":"Xu","sequence":"additional","affiliation":[{"name":"Institute of Marine Drugs Guangxi University of Chinese Medicine  Nanning P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhonghui","family":"Ma","sequence":"additional","affiliation":[{"name":"National Demonstration Center For Experimental Plant Science Education College of Agriculture Guangxi University  Nanning P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2998-8617","authenticated-orcid":false,"given":"Zhiwei","family":"Su","sequence":"additional","affiliation":[{"name":"National Demonstration Center For Experimental Plant Science Education College of Agriculture Guangxi University  Nanning P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,16]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytochem.2021.112769"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S31636"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.853119"},{"key":"e_1_2_10_5_1","unstructured":"Z. W.Su C. H.Gao andS. 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