{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T20:16:54Z","timestamp":1788898614523,"version":"build-2803163510"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T00:00:00Z","timestamp":1763078400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T00:00:00Z","timestamp":1763078400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    This study investigates the neuroprotective effects of triterpenoid compounds from\n                    <jats:italic>Rosa laevigata<\/jats:italic>\n                    Michx. roots against Alzheimer's disease (AD). A total of 62 compounds were identified using ultra\u2010performance liquid chromatography\u2010Orbitrap\u2010tandem mass spectrometry analysis, which included 55 triterpenoids and seven flavonoids. Among 15 isolated compounds, compound\n                    <jats:bold>13<\/jats:bold>\n                    demonstrated the strongest acetylcholinesterase (AChE) inhibitory activity, with an IC\n                    <jats:sub>50<\/jats:sub>\n                    of 3.38 \u00b5mol\/L, and a maximum inhibition rate of 87.20%. Compound\n                    <jats:bold>13<\/jats:bold>\n                    exhibited favorable and stable binding with AChE in molecular docking studies, whilst demonstrating mixed\u2010type inhibition in enzyme kinetics. In the H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    \u2010induced SH\u2010SY5Y cell model, compound\n                    <jats:bold>13<\/jats:bold>\n                    exhibited 84.45% viability at 25 \u00b5mol\/L, surpassing Trolox's 74.16%. Research indicates that\n                    <jats:italic>R. laevigata<\/jats:italic>\n                    Michx. root triterpenes exert neuroprotective effects through AChE inhibition and antioxidant activity, with compound 13 potentially serving as a multi\u2010target lead compound for treating AD.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202502742","type":"journal-article","created":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T17:57:06Z","timestamp":1763143026000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Neuroprotective Effects of Triterpenoids From\n                    <i>Rosa laevigata<\/i>\n                    Root: Identification, Molecular Docking, and In Vitro Evaluation for Alzheimer's Disease Treatment"],"prefix":"10.1002","volume":"23","author":[{"given":"Fei","family":"Xu","sequence":"first","affiliation":[{"name":"Institute of Functional Molecules Shenyang University of Chemical Technology  Shenyang P. R. China"},{"name":"College of Chemical Engineering Shenyang University of Chemical Technology  Shenyang P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxing","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Functional Molecules Shenyang University of Chemical Technology  Shenyang P. R. China"},{"name":"College of Chemical Engineering Shenyang University of Chemical Technology  Shenyang P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pinyi","family":"Gao","sequence":"additional","affiliation":[{"name":"College of Chemical Engineering Shenyang University of Chemical Technology  Shenyang P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danqi","family":"Li","sequence":"additional","affiliation":[{"name":"Institute of Functional Molecules Shenyang University of Chemical Technology  Shenyang P. R. China"},{"name":"National\u2010Local Joint Engineering Laboratory for Development of Boron and Magnesium Resources and Fine Chemical Technology Shenyang University of Chemical Technology  Shenyang P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuegui","family":"Liu","sequence":"additional","affiliation":[{"name":"Institute of Functional Molecules Shenyang University of Chemical Technology  Shenyang P. R. China"},{"name":"National\u2010Local Joint Engineering Laboratory for Development of Boron and Magnesium Resources and Fine Chemical Technology Shenyang University of Chemical Technology  Shenyang P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,14]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-023-01588-0"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23115938"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.18.9989"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/toxics8020021"},{"key":"e_1_2_9_6_1","volume-title":"Pharmacopoeia of the People's Republic of China","author":"National Pharmacopoeia Committee","year":"2020"},{"key":"e_1_2_9_7_1","first-page":"167","article-title":"The Summary of Medicinal History and Modern Research on the Root of Rosa laevigata","volume":"6","author":"Tan N. X.","year":"2010","journal-title":"Journal of Asia\u2010Pacific Traditional Medicine"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules13092229"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2024.135116"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00894-018-3609-8"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules24234228"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.3393"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.1012265"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25204672"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/np1007922"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph18020253"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2024.1494277"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules22112029"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja9944296"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2025.117309"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsptsci.2c00120"}],"container-title":["Chemistry &amp; Biodiversity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbdv.202502742","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cbdv.202502742","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbdv.202502742","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T07:58:15Z","timestamp":1785484695000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cbdv.202502742"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,14]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1002\/cbdv.202502742"],"URL":"https:\/\/doi.org\/10.1002\/cbdv.202502742","archive":["Portico"],"relation":{},"ISSN":["1612-1872","1612-1880"],"issn-type":[{"value":"1612-1872","type":"print"},{"value":"1612-1880","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,14]]},"assertion":[{"value":"2025-08-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e02742"}}