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SYSU\u2010M4, isolated from mangrove sediments and grown on rice medium, yielded sixteen alkaloids (\n                    <jats:bold>1<\/jats:bold>\n                    \u2013\n                    <jats:bold>16<\/jats:bold>\n                    ), including two new compounds dihydroversimide B (\n                    <jats:bold>1<\/jats:bold>\n                    ) and glulisine B (\n                    <jats:bold>3<\/jats:bold>\n                    ), two new natural products 6\n                    <jats:italic>S<\/jats:italic>\n                    \u2010dihydroversimide (\n                    <jats:bold>2<\/jats:bold>\n                    ) and 2,3,6,7\u2010tetrahydro\u20103\u2010isobutylpyrrolo[1,2\u2010a]pyrazine\u20101,4\u2010dione (\n                    <jats:bold>5<\/jats:bold>\n                    ), along with twelve known alkaloids. 1D and 2D NMR data analysis established their structures. The absolute configurations of Compounds\n                    <jats:bold>1<\/jats:bold>\n                    and\n                    <jats:bold>2<\/jats:bold>\n                    were assigned using an integrated approach involving electronic circular dichroism (ECD) and\n                    <jats:sup>13<\/jats:sup>\n                    C NMR calculations, as well as DP4+ analysis. The anti\u2010neuroinflammatory and acetylcholinesterase (AChE) inhibitory activities for selected isolated alkaloids were tested. Specifically, Compounds\n                    <jats:bold>1<\/jats:bold>\n                    ,\n                    <jats:bold>7<\/jats:bold>\n                    ,\n                    <jats:bold>10<\/jats:bold>\n                    , and\n                    <jats:bold>11<\/jats:bold>\n                    dose\u2010dependently suppressed lipopolysaccharide (LPS)\u2010induced nitric oxide (NO) accumulation in BV\u20102 cells at 20.0\u00a0\u00b5g\/mL and without cytotoxicity at this effective concentration. Notably, these compounds moderately attenuated LPS\u2010stimulated BV\u20102 cell activation by downregulating interleukin\u20101\u03b2 (IL\u20101\u03b2), indicating their potential anti\u2010inflammatory effects. Additionally, Compound\n                    <jats:bold>11<\/jats:bold>\n                    exhibited slight to moderate AChE inhibitory activity, with an IC\n                    <jats:sub>50<\/jats:sub>\n                    of 82.2\u00a0\u00b5M.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202502750","type":"journal-article","created":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T17:59:47Z","timestamp":1765907987000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Bioactive Alkaloids With Anti\u2010Neuroinflammatory Activity From Mangrove Sediment\u2010Derived Fungus\n                    <i>Pseudallescheria<\/i>\n                    sp. SYSU\u2010M4"],"prefix":"10.1002","volume":"23","author":[{"given":"Huangsheng","family":"Feng","sequence":"first","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Aquatic Product Processing and Safety, Guangdong Province Engineering Laboratory for Marine Biological Products, Guangdong Provincial Engineering Technology Research Center of Seafood, Key Laboratory of Advanced Processing of Aquatic Product of Guangdong Higher Education Institution, Zhanjiang Municipal Key Laboratory of Marine Drugs and Nutrition for Brain Health, Research Institute for Marine Drugs and Nutrition, Shenzhen Institute of Guangdong Ocean..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Senhua","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Marine Sciences Sun Yat\u2010Sen University  Zhuhai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heng","family":"Guo","sequence":"additional","affiliation":[{"name":"School of Marine Sciences Sun Yat\u2010Sen University  Zhuhai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yining","family":"Xu","sequence":"additional","affiliation":[{"name":"School of Marine Sciences Sun Yat\u2010Sen University  Zhuhai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Chen","sequence":"additional","affiliation":[{"name":"Southern Laboratory of Ocean Science and Engineering (Guangdong, Zhuhai)  Zhuhai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lan","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Marine Sciences Sun Yat\u2010Sen University  Zhuhai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuxin","family":"Qin","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Aquatic Product Processing and Safety, Guangdong Province Engineering Laboratory for Marine Biological Products, Guangdong Provincial Engineering Technology Research Center of Seafood, Key Laboratory of Advanced Processing of Aquatic Product of Guangdong Higher Education Institution, Zhanjiang Municipal Key Laboratory of Marine Drugs and Nutrition for Brain Health, Research Institute for Marine Drugs and Nutrition, Shenzhen Institute of Guangdong Ocean..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiyou","family":"Yang","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Aquatic Product Processing and Safety, Guangdong Province Engineering Laboratory for Marine Biological Products, Guangdong Provincial Engineering Technology Research Center of Seafood, Key Laboratory of Advanced Processing of Aquatic Product of Guangdong Higher Education Institution, Zhanjiang Municipal Key Laboratory of Marine Drugs and Nutrition for Brain Health, Research Institute for Marine Drugs and Nutrition, Shenzhen Institute of Guangdong Ocean..."},{"name":"Collaborative Innovation Center of Seafood Deep Processing Dalian Polytechnic University  Dalian China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weixia","family":"Li","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Aquatic Product Processing and Safety, Guangdong Province Engineering Laboratory for Marine Biological Products, Guangdong Provincial Engineering Technology Research Center of Seafood, Key Laboratory of Advanced Processing of Aquatic Product of Guangdong Higher Education Institution, Zhanjiang Municipal Key Laboratory of Marine Drugs and Nutrition for Brain Health, Research Institute for Marine Drugs and Nutrition, Shenzhen Institute of Guangdong Ocean..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Aquatic Product Processing and Safety, Guangdong Province Engineering Laboratory for Marine Biological Products, Guangdong Provincial Engineering Technology Research Center of Seafood, Key Laboratory of Advanced Processing of Aquatic Product of Guangdong Higher Education Institution, Zhanjiang Municipal Key Laboratory of Marine Drugs and Nutrition for Brain Health, Research Institute for Marine Drugs and Nutrition, Shenzhen Institute of Guangdong Ocean..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4984-8497","authenticated-orcid":false,"given":"Yayue","family":"Liu","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Aquatic Product Processing and Safety, Guangdong Province Engineering Laboratory for Marine Biological Products, Guangdong Provincial Engineering Technology Research Center of Seafood, Key Laboratory of Advanced Processing of Aquatic Product of Guangdong Higher Education Institution, Zhanjiang Municipal Key Laboratory of Marine Drugs and Nutrition for Brain Health, Research Institute for Marine Drugs and 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