{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T16:59:39Z","timestamp":1785085179358,"version":"3.55.0"},"reference-count":40,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T00:00:00Z","timestamp":1778457600000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Inflammation and oxidative stress are closely linked pathological processes, characterized by the excessive generation of reactive oxygen species, which activate redox\u2010sensitive transcription factors, initiating a cascade of pro\u2010inflammatory cytokine release that sustains cellular and tissue damage. This study examined two bioactive compounds derived from\n                    <jats:italic>Symplocos sumuntia<\/jats:italic>\n                    Buch\u2010Ham. ex D Don for their anti\u2010inflammatory properties. Network pharmacology analysis proposed RELA, NFKBIA, and PTGS2 as critical molecular targets, suggesting the suppression of pro\u2010inflammatory cytokines through the NF\u2010\u03baB pathway. Phytochemical profiling showed that the crude extract and ETOAc fraction contained high phenolic compounds. Additionally, in vitro and in silico studies further substantiated the antioxidant properties of this plant. These findings highlight the dual anti\u2010inflammatory and antioxidant properties of\n                    <jats:italic>S. sumuntia<\/jats:italic>\n                    , affirming its potential as a natural therapeutic candidate for inflammatory disorders. A validated HPLC\u2013MS method was established to qualify active ingredients, which made utilization of the quality of\n                    <jats:italic>S. sumuntia<\/jats:italic>\n                    \u2010based products on the market by controlling the content of these active constituents. Our study characterized the anti\u2010inflammatory potentials of this plant through assessing the anti\u2010inflammatory mechanisms of its active ingredients and highlighted that this plant might be a promising candidate for the development of anti\u2010inflammatory and antioxidant products.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202502756","type":"journal-article","created":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T05:45:07Z","timestamp":1778564707000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Integrated Network Pharmacology, Molecular Docking, and Analysis of Active Constituents of\n                    <i>Symplocos sumuntia<\/i>\n                    Along With Their Antioxidative Activity"],"prefix":"10.1002","volume":"23","author":[{"given":"Tran Thu","family":"Huong","sequence":"first","affiliation":[{"name":"Hanoi University of Science and Technology  Hanoi 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