{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T07:00:43Z","timestamp":1775890843789,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T00:00:00Z","timestamp":1770249600000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22307041"],"award-info":[{"award-number":["22307041"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Twelve monoterpene indole alkaloids (\n                    <jats:bold>1<\/jats:bold>\n                    \u2012\n                    <jats:bold>12<\/jats:bold>\n                    ), classified into six diverse types, ajmalicine (\n                    <jats:bold>1<\/jats:bold>\n                    ,\n                    <jats:bold>3<\/jats:bold>\n                    , and\n                    <jats:bold>4<\/jats:bold>\n                    ), tubotaiwine (\n                    <jats:bold>2<\/jats:bold>\n                    ), aspidosperma (\n                    <jats:bold>5<\/jats:bold>\n                    and\n                    <jats:bold>6<\/jats:bold>\n                    ), peraksine (\n                    <jats:bold>7<\/jats:bold>\n                    and\n                    <jats:bold>8<\/jats:bold>\n                    ), eburnane (\n                    <jats:bold>9<\/jats:bold>\n                    and\n                    <jats:bold>10<\/jats:bold>\n                    ), and heteroyohimbine (\n                    <jats:bold>11<\/jats:bold>\n                    and\n                    <jats:bold>12<\/jats:bold>\n                    ), respectively, were isolated from the branches and leaves of\n                    <jats:italic>Alstonia mairei<\/jats:italic>\n                    . Their structures were elucidated via the spectroscopic data interpretation, electronic circular dichroism calculations, single crystal X\u2010ray diffraction analysis, and comparison with literature. Notably, mareines C (1) and D (2) represent the first examples of the natural ajmalicine alkaloid possessing an additional carbon connecting with C\u20103 and 12\u2010hydroxytubotaiwine alkaloid, respectively. Compounds\n                    <jats:bold>3<\/jats:bold>\n                    and\n                    <jats:bold>6<\/jats:bold>\n                    \u2012\n                    <jats:bold>12<\/jats:bold>\n                    were obtained from\n                    <jats:italic>Alstonia mairei<\/jats:italic>\n                    for the first time. In addition, all isolates were evaluated for their anti\u2010inflammatory activities in vitro, and compounds\n                    <jats:bold>1<\/jats:bold>\n                    ,\n                    <jats:bold>4<\/jats:bold>\n                    ,\n                    <jats:bold>7<\/jats:bold>\n                    \/\n                    <jats:bold>8<\/jats:bold>\n                    ,\n                    <jats:bold>11<\/jats:bold>\n                    , and\n                    <jats:bold>12<\/jats:bold>\n                    exhibited potent inhibitory activities on the lipopolysaccharide\u2010induced nitric oxide production in RAW264.7 mouse macrophages with IC\n                    <jats:sub>50<\/jats:sub>\n                    values ranging from 4.4 to 20.4 \u00b5M.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202502762","type":"journal-article","created":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T21:13:58Z","timestamp":1770326038000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Anti\u2010Inflammatory Monoterpene Indole Alkaloids From\n                    <i>Alstonia mairei<\/i>"],"prefix":"10.1002","volume":"23","author":[{"given":"Pengfei","family":"Jin","sequence":"first","affiliation":[{"name":"Department of Pharmacy Wuhan No. 1 Hospital  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guijuan","family":"Zheng","sequence":"additional","affiliation":[{"name":"School of Medicine, Institute of Cardiovascular Diseases, Hubei Province Key Laboratory of Occupational Hazard Identification and Control Wuhan University of Science and Technology  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yimiao","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Medicine, Institute of Cardiovascular Diseases, Hubei Province Key Laboratory of Occupational Hazard Identification and Control Wuhan University of Science and Technology  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinqiao","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences South\u2010Central Minzu University  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-6012-3982","authenticated-orcid":false,"given":"Hongfeng","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Wuhan No. 1 Hospital  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,5]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/np960324u"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1039\/D3NP00048F"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11101\u2010023\u201009871\u20102"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26020488"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2024.117921"},{"key":"e_1_2_10_7_1","volume-title":"Zhong Hua Ben Cao","author":"Editorial board of Chinese Materia Medica, State Administration of Traditional Chinese Medicine","year":"1999"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/hlca.201000040"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/10286020.2017.1313242"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2021.132277"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jnatprod.1c00062"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/cjoc.202100077"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2021.104870"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2707\u20103688(23)00047\u2010X"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/14786419.2024.2361470"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0031\u20109422(89)80218\u20103"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100028\u20101097681"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0031\u20109422(90)80208\u2010X"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytochem.2023.113610"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0040\u20104020(72)88129\u20108"},{"key":"e_1_2_10_21_1","first-page":"1653","article-title":"Chemical Constituents in the Twigs and Leaves of Alstonia mairei L\u00e9vl","volume":"23","author":"Qin W. 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