{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T08:01:43Z","timestamp":1785484903833,"version":"3.56.0"},"reference-count":66,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T00:00:00Z","timestamp":1768348800000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The objective of the work is to present a comprehensive analysis of the bioactive metabolites present in\n                    <jats:italic>Pongamia pinnata<\/jats:italic>\n                    (\n                    <jats:italic>Pp<\/jats:italic>\n                    ) stems. The radioprotective properties of\n                    <jats:italic>Pp<\/jats:italic>\n                    against gamma radiation\u2010induced inflammation in vivo were also clarified. A single acute dose of whole\u2010body gamma radiation (7\u00a0Gy) was administered to the rats. For 10 days, the herbal extract was administered orally by gavage at doses of 300 and 1000\u00a0mg\/kg. The irradiated group administered with\n                    <jats:italic>Pp<\/jats:italic>\n                    70% ethanolic extract showed a significant reduction in testicular and renal oxidative stress markers, such as reduced glutathione and malondialdehyde. Pretreatment with\n                    <jats:italic>Pp<\/jats:italic>\n                    showed notable improvements in biomarkers (nuclear factor kappa B [NF\u2010\u03baB], phosphoinositide 3\u2010kinases [PI3K], Akt, and mTOR) in testis and renal tissues. Both the incidence of sperm head abnormalities and the serum levels of urea and creatinine were markedly reduced in irradiated rats that had been pretreated with\n                    <jats:italic>Pp<\/jats:italic>\n                    herbal extract. The docking study concentrated on the ability of the herbal extract's most active metabolites, \u03b2\u2010sitosterol, stigmasterol, betulinic acid, and ponganone XI, to bind to the NF\u2010\u03baB, PI3K, Akt, and mTOR target sites.\n                    <jats:italic>Pp<\/jats:italic>\n                    stem includes a variety of pharmacological properties that modulate the PI3K\/Akt\/mTOR pathway, including possible antioxidant and anti\u2010inflammatory compounds.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202502776","type":"journal-article","created":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T15:02:17Z","timestamp":1768402937000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Potent Antioxidant and Anti\u2010Inflammatory Metabolites of\n                    <i>Pongamia pinnata<\/i>\n                    Stems and Their Role in NF\u2010\u03baB and PI3K\/AKT\/mTOR Signaling Pathways Regulation in Irradiated Rats"],"prefix":"10.1002","volume":"23","author":[{"given":"Ahmed","family":"Ismail","sequence":"first","affiliation":[{"name":"Pharmacognosy Department, Faculty of Pharmacy Fayoum University  Fayoum Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0540-2784","authenticated-orcid":false,"given":"Fatma Y.","family":"Abdou","sequence":"additional","affiliation":[{"name":"Drug Radiation Research Department, Pharmacology and Toxicology Lab National Center for Radiation Research and Technology, Egyptian Atomic Energy Authority  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ola A.","family":"Gharib","sequence":"additional","affiliation":[{"name":"Drug Radiation Research Department National Center for Radiation Research and Technology, Egyptian Atomic Energy Authority  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asrar M.","family":"Hawas","sequence":"additional","affiliation":[{"name":"Drug Radiation Research Department National Center for Radiation Research and Technology, Egyptian Atomic Energy Authority  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noheir","family":"Sherif","sequence":"additional","affiliation":[{"name":"Drug Radiation Research Department National Center for Radiation Research and Technology, Egyptian Atomic Energy Authority  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdulrahman M.","family":"Saleh","sequence":"additional","affiliation":[{"name":"Pharmaceutical Chemistry Department, Faculty of Pharmacy Cairo University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kholoud M.","family":"Abdelsalam","sequence":"additional","affiliation":[{"name":"Faculty of Computer and Information Technology Bioinformatics Department Menofia University  Shibin Al Kawm Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Aboelmagd","sequence":"additional","affiliation":[{"name":"Pharmacognosy Department National Research Centre  Giza Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,14]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2006.06.051"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lwt.2005.10.001"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules17043917"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378\u20108741(01)00333\u20106"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcme.2015.12.002"},{"issue":"3","key":"e_1_2_11_7_1","first-page":"50","article-title":"Ethnopharmacology, Phytochemistry and Pharmacological Evaluation of Pongamia Pinnata (L.) 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