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This study aimed to develop 2,4\u2010substituted thiazoles with dual anti\u2010inflammatory and anticancer potential. A series of 20 2,4\u2010substituted thiazoles 3(a\u2013t) was synthesized and evaluated for biological efficacy. Antioxidant screening revealed compound 3t showed strong inhibition (IC\n                    <jats:sub>50<\/jats:sub>\n                    = 26.53 \u00b1 0.16\u00a0\u00b5g\/mL). Anti\u2010inflammatory protein denaturation assays demonstrated significant inhibition by compounds 3p and 3r (IC\n                    <jats:sub>50<\/jats:sub>\n                    = 6.50 \u00b1 0.89 and 10.72 \u00b1 4.36\u00a0\u00b5g\/mL). Cytotoxicity screening against MCF\u20107 breast cancer cells showed 3r had higher antiproliferative potency (IC\n                    <jats:sub>50<\/jats:sub>\n                    = 17.44\u00a0\u00b5g\/mL) than 3p, confirmed by cell cycle analysis and dual fluorescent staining, indicating mild apoptosis and suppressed proliferation. In silico ADME, drug\u2010likeness, and network pharmacology analyses supported favorable pharmacokinetic profiles and identified potential molecular targets. Molecular docking revealed strong binding interactions. Overall, compound 4\u2010(2\u2010(2\u2010((1\u2010benzyl\u20101\n                    <jats:italic>H<\/jats:italic>\n                    \u2010indol\u20103\u2010yl)methylene)hydrazinyl)thiazol\u20104\u2010yl)benzonitrile (3r) emerges as a promising multifunctional lead, highlighting the potential of 2,4\u2010substituted thiazoles scaffolds in targeting inflammation\u2010associated breast cancer. The novelty of this work lies in demonstrating the dual efficacy of these hybrids in modulating inflammatory and proliferative pathways, guiding future mechanistic and in vivo investigations.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202502784","type":"journal-article","created":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T09:31:57Z","timestamp":1776245517000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Development of 2,4\u2010Substituted Thiazoles as Dual Inhibitors of Inflammation and Breast\u2010Cancer Progression"],"prefix":"10.1002","volume":"23","author":[{"given":"Thiviya","family":"B M","sequence":"first","affiliation":[{"name":"Department of Chemistry, School of Advanced Sciences Vellore Institute of Technology  Vellore Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8294-0933","authenticated-orcid":false,"given":"Manju","family":"S L","sequence":"additional","affiliation":[{"name":"Department of Chemistry, School of Advanced Sciences Vellore Institute of Technology  Vellore Tamil Nadu 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