{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T23:32:00Z","timestamp":1789687920054,"version":"4.0.1"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T00:00:00Z","timestamp":1763078400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T00:00:00Z","timestamp":1763078400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32272584"],"award-info":[{"award-number":["32272584"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    In this study, a series of 22 novel pyrazole sulfonamide derivatives incorporating a 1,3,4\u2010oxadiazole moiety were designed and synthesized for the development of new antifungal agents. The target compounds were prepared by introducing the 1,3,4\u2010oxadiazole group at the 4\u2010position of the phenylpyrazole scaffold, followed by coupling with benzenesulfonyl chlorides. Antifungal activity evaluation revealed that compound\n                    <jats:bold>c17<\/jats:bold>\n                    exhibited excellent efficacy against\n                    <jats:italic>Valsa mali<\/jats:italic>\n                    (EC\n                    <jats:sub>50<\/jats:sub>\n                    \u00a0=\u00a013.49\u00a0mg\/L), superior to the commercial fungicide\n                    <jats:bold>boscalid<\/jats:bold>\n                    (EC\n                    <jats:sub>50<\/jats:sub>\n                    \u00a0=\u00a013.91\u00a0mg\/L). Meanwhile, compound\n                    <jats:bold>c11<\/jats:bold>\n                    showed significant activity against\n                    <jats:italic>Botrytis cinerea<\/jats:italic>\n                    (EC\n                    <jats:sub>50<\/jats:sub>\n                    \u00a0=\u00a013.85\u00a0mg\/L). In vivo assays demonstrated that\n                    <jats:bold>c17<\/jats:bold>\n                    effectively controlled\n                    <jats:italic>V. mali<\/jats:italic>\n                    infection on apple fruits. Preliminary investigation into the antifungal mechanism indicated that\n                    <jats:bold>c17<\/jats:bold>\n                    disrupts the hyphal ultrastructure, and cellular content leakage assays suggested that its action likely involves compromising the plasma membrane integrity of\n                    <jats:italic>V. mali<\/jats:italic>\n                    hyphae. These findings provide valuable insights for the development of phenylpyrazole sulfonamide fungicides bearing 1,3,4\u2010oxadiazole pharmacophores.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202502798","type":"journal-article","created":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T17:53:11Z","timestamp":1763142791000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Design, Synthesis, and Antifungal Activity Evaluation of Novel Pyrazole Sulfonamide Derivatives Containing 1,3,4\u2010Oxadiazole Moiety"],"prefix":"10.1002","volume":"23","author":[{"given":"Mingjie","family":"Chu","sequence":"first","affiliation":[{"name":"College of Materials and Chemistry &amp; School of Plant Protection Anhui Agricultural University  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunxiao","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Materials and Chemistry &amp; School of Plant Protection Anhui Agricultural University  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zonghan","family":"Xu","sequence":"additional","affiliation":[{"name":"College of Materials and Chemistry &amp; School of Plant Protection Anhui Agricultural University  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8535-0015","authenticated-orcid":false,"given":"Xianhai","family":"Lv","sequence":"additional","affiliation":[{"name":"College of Materials and Chemistry &amp; School of Plant Protection Anhui Agricultural University  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,14]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1185383"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2019.00214"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.3852\/09\u2010165"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms8091431"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2022.934857"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2022.962619"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.2147\/IDR.S124918"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.1c02454"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.202401031"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.4c08825"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.3c04869"},{"key":"e_1_2_8_13_1","unstructured":"A.Fatima S.Aslam S.Janiad et\u00a0al. \u201cSynthesis and Biological Evaluation of Rationally Designed Pyrazoles as Insecticidal Agents \u201dMololecular Diversity(2025) https:\/\/doi.org\/10.1007\/s11030\u2010024\u201011094\u20102."},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ps.5591"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cclet.2025.110912"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.1c06654"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2010.09.031"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.9b02734"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arabjc.2024.105758"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.201900570"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11164\u2010022\u201004839\u2010x"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11164\u2010019\u201004015\u20108"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.6b00443"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1021\/np501015m"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.4c08684"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.202200608"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.202201020"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.2174\/1385272822666180122153839"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.2c04708"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.2174\/0115734064354700241202174614"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.4c05050"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.202101032"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.4c11375"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.indcrop.2024.119751"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/ps.8306"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.2c01901"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pestbp.2024.106229"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/ps.8563"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.1c01887"}],"container-title":["Chemistry &amp; 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