{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T03:44:22Z","timestamp":1790480662728,"version":"4.1.0"},"reference-count":87,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T00:00:00Z","timestamp":1785024000000},"content-version":"vor","delay-in-days":25,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100017245","name":"UNIFOR","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100017245","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005283","name":"Funda\u00e7\u00e3o Cearense de Apoio ao Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["PS1\u201000186\u201000240.01.00\/21"],"award-info":[{"award-number":["PS1\u201000186\u201000240.01.00\/21"]}],"id":[{"id":"10.13039\/501100005283","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005283","name":"Funda\u00e7\u00e3o Cearense de Apoio ao Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["UNI\u20100210\u201000160.01.00\/23"],"award-info":[{"award-number":["UNI\u20100210\u201000160.01.00\/23"]}],"id":[{"id":"10.13039\/501100005283","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005283","name":"Funda\u00e7\u00e3o Cearense de Apoio ao Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["FPD\u20100213\u201000140.01.00\/23"],"award-info":[{"award-number":["FPD\u20100213\u201000140.01.00\/23"]}],"id":[{"id":"10.13039\/501100005283","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Lippia grata Schauer, a species of the Verbenaceae family, is native to the Northeastern region of Brazil and widely distributed in the Seasonally Dry Tropical Forest. Commonly known as \u201calecrim\u2010da\u2010chapada,\u201d this medicinal plant stands out for its antimicrobial and pharmacological properties, mainly due to its essential oils rich in thymol and carvacrol. These compounds confer antifungal, antibiotic, anti\u2010inflammatory, antioxidant, and antitumor activities, highlighting their potential in folk medicine. Based on this, the present study aimed to use in silico and in vivo tests in adult zebrafish as an alternative method to investigate the therapeutic potential of the essential oil of Lippia grata (EOLg) and its main constituent thymol (2\u2010isopropyl\u20105\u2010methylphenol) in the treatment of seizures and anxiety induced by alcohol withdrawal. Initially, adult zebrafish (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a06\/group) were treated with EOLg and thymol (0.01 or \u00a00.1 or 1.0\u00a0mg\/mL; 20\u00a0\u00b5L; oral administration) and assessed for anxiolytic, convulsive, and acute toxicity effects after 96\u00a0h. Subsequently, the potential anxiolytic\u2010like, anticonvulsant effects, the possible GABAergic mechanism, and the efficacy of the samples in treating anxiety induced by alcohol withdrawal in adult zebrafish were investigated. Furthermore, molecular docking simulations of thymol with GABAergic receptors were performed. Preliminary results showed that EOLg and thymol were nontoxic and did not exhibit sedative effects in ZFa. Both demonstrated anticonvulsant and anxiolytic effects involving GABA\n                    <jats:sub>A<\/jats:sub>\n                    receptors and were effective in treating anxiety induced by alcohol withdrawal in the chronic test. These in vivo effects were corroborated by the potential interaction between thymol and the GABA\n                    <jats:sub>A<\/jats:sub>\n                    receptor identified in the in silico analysis.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202502870","type":"journal-article","created":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T18:06:29Z","timestamp":1785089189000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["<i>Lippia grata<\/i>\n                    Schauer: Essential Oil as a Source of the Phytotherapeutic Thymol for the Treatment of Seizures and Anxiety Induced by Alcohol Withdrawal in Adult Zebrafish"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5854-6709","authenticated-orcid":false,"given":"Luiz F. Wemmenson Gon\u00e7alves","family":"Moura","sequence":"first","affiliation":[{"name":"Programa de P\u00f3s\u2010Gradua\u00e7\u00e3o em Nutri\u00e7\u00e3o e Sa\u00fade (PPGNS) Laborat\u00f3rio de Qu\u00edmica Inorg\u00e2nica (LQUIN) Campus do Itaperi Universidade Estadual do Cear\u00e1  Fortaleza Cear\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2568-0519","authenticated-orcid":false,"given":"Maria Rayane C.","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s\u2010Gradua\u00e7\u00e3o em Nutri\u00e7\u00e3o e Sa\u00fade (PPGNS) Laborat\u00f3rio de Qu\u00edmica Inorg\u00e2nica (LQUIN) Campus do Itaperi Universidade Estadual do Cear\u00e1  Fortaleza Cear\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1183-525X","authenticated-orcid":false,"given":"Gabriela A.","family":"do Nascimento","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s\u2010Gradua\u00e7\u00e3o em Nutri\u00e7\u00e3o e Sa\u00fade (PPGNS) Laborat\u00f3rio de Qu\u00edmica Inorg\u00e2nica (LQUIN) Campus do Itaperi Universidade Estadual do Cear\u00e1  Fortaleza Cear\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-8160-6973","authenticated-orcid":false,"given":"Jo\u00e3o Gabriel L.","family":"da Silva","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s\u2010Gradua\u00e7\u00e3o em Nutri\u00e7\u00e3o e Sa\u00fade (PPGNS) Laborat\u00f3rio de Qu\u00edmica Inorg\u00e2nica (LQUIN) Campus do Itaperi Universidade Estadual do Cear\u00e1  Fortaleza Cear\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8566-5201","authenticated-orcid":false,"given":"Paulo Adenes T.","family":"Coelho","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s\u2010Gradua\u00e7\u00e3o em Nutri\u00e7\u00e3o e Sa\u00fade (PPGNS) Laborat\u00f3rio de Qu\u00edmica Inorg\u00e2nica (LQUIN) Campus do Itaperi Universidade Estadual do Cear\u00e1  Fortaleza Cear\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3362-2837","authenticated-orcid":false,"given":"Lorena S.","family":"Lima","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s\u2010Gradua\u00e7\u00e3o em Nutri\u00e7\u00e3o e Sa\u00fade (PPGNS) Laborat\u00f3rio de Qu\u00edmica Inorg\u00e2nica (LQUIN) Campus do Itaperi Universidade Estadual do Cear\u00e1  Fortaleza Cear\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4117-2277","authenticated-orcid":false,"given":"Sacha Aubrey A. 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Naturais e Biotecnologia (LBPNB) Campus CECITEC Universidade Estadual do Cear\u00e1  Tau\u00e1 Cear\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,26]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2018.10.023"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v26.i22.2916"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2020.107384"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11920\u2010019\u20101029\u20109"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2025.01.004"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/mpr.1836"},{"key":"e_1_2_10_8_1","unstructured":"S.Dattani L.Rod\u00e9s\u2010Guirao H.Ritchie andM.Roser Mental Health. Our World in Data. \u201cMental Health\u201d Published online at OurWorldinData.org. Retrieved from:https:\/\/ourworldindata.org\/mental\u2010health."},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2021.12.009"},{"key":"e_1_2_10_10_1","doi-asserted-by":"crossref","unstructured":"K. L.SzuhanyandN. M.Simon Anxiety Disorders JAMA328 no.24(2022):2431 https:\/\/doi.org\/10.1001\/jama.2022.22744.","DOI":"10.1001\/jama.2022.22744"},{"key":"e_1_2_10_11_1","volume-title":"Benzodiazepines","author":"Bounds C. 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