{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T12:47:02Z","timestamp":1775998022741,"version":"3.50.1"},"reference-count":49,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T00:00:00Z","timestamp":1774224000000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Functionalized dendrimeric nanoparticles (BH40\u2010PEG\u2010F127\u2010FA) were synthesized to develop a targeted delivery platform for combined therapeutic and imaging applications. Structural confirmation through FT\u2010IR,\n                    <jats:sup>1<\/jats:sup>\n                    H\u2010NMR,\n                    <jats:sup>13<\/jats:sup>\n                    C\u2010NMR, and MALDI\u2010TOF mass spectrometry verified the successful formation of the macromolecular architecture. The nanoparticles exhibited hydrodynamic sizes of 190\u2013255\u00a0nm, while transmission electron microscopy revealed micellar structures ranging from 35 to 190\u00a0nm. The critical micelle concentration of the copolymer was determined as approximately 0.001\u00a0mg\/mL. Thermal analyses demonstrated the stability of BH40\u2010PEG and BH40\u2010PEG\u2010F127\u2010FA. Gd\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>3<\/jats:sub>\n                    and sphingosine kinase inhibitors (SKI\u2010I\/II) were incorporated using a supercritical CO\n                    <jats:sub>2<\/jats:sub>\n                    method, and structural integrity after loading was confirmed by FT\u2010IR and x\u2010ray diffraction. Drug\u2010release studies performed in phosphate\u2010buffered saline (pH 6.7, 37\u00b0C) indicated a sustained release over 192\u00a0h. Cytotoxicity assays on A549 lung cancer cells and Beas\u20102B healthy epithelial cells revealed selective antiproliferative activity, while confocal microscopy demonstrated treatment\u2010induced morphological alterations. Overall, BH40\u2010PEG\u2010F127\u2010FA nanoparticles show strong potential as biocompatible carriers for targeted therapy and multimodal imaging.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202502899","type":"journal-article","created":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T04:18:30Z","timestamp":1774325910000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Preparation of Novel Dendrimeric Hyperbranched Polymer\u2010Gd\n                    <sub>2<\/sub>\n                    O\n                    <sub>3<\/sub>\n                    Composites Loaded With Sphingosine Inhibitor\u2010I\/II"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0211-1006","authenticated-orcid":false,"given":"Emine","family":"Kutlu","sequence":"first","affiliation":[{"name":"Department of Chemistry Faculty of Arts and Sciences Burdur Mehmet Akif Ersoy University  Burdur Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatih Mehmet","family":"Emen","sequence":"additional","affiliation":[{"name":"Department of Chemistry Faculty of Arts and Sciences Burdur Mehmet Akif Ersoy University  Burdur Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad Asim","family":"Ali","sequence":"additional","affiliation":[{"name":"Department of Chemistry Faculty of Arts and Sciences Burdur Mehmet Akif Ersoy University  Burdur Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hatice Mehtap","family":"Kutlu","sequence":"additional","affiliation":[{"name":"Department of Advanced Technologies Eskisehir Technical University  Eskisehir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Canan Vejselova","family":"Sezer","sequence":"additional","affiliation":[{"name":"Faculty of Arts and Sciences Department of Biology Kutahya Dumlup\u0131nar University  K\u00fctahya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,3,23]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2015.02.025"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2011.04.001"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.21037\/atm.2018.04.04"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-018-1448-3"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/183624"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-7091-1511-4_5"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2013.5469"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2006.08.052"},{"key":"e_1_2_8_10_1","first-page":"25","volume-title":"Sphingolipids in Cancer","author":"Saddoughi S. 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