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This systematic review evaluates the therapeutic potential of\n                    <jats:italic>Ginkgo biloba<\/jats:italic>\n                    (GB), particularly the standardized extract EGb 761, in TBI management. A comprehensive literature search was conducted in PubMed, Scopus, and Web of Science up to February 2026. Sixty\u2010five studies met the inclusion criteria, including 42 in vivo experimental studies and 23 clinical trials examining neuroprotective, cognitive, behavioral, or functional outcomes following GB administration. Preclinical evidence consistently demonstrates that\n                    <jats:italic>Ginkgo biloba<\/jats:italic>\n                    (GB) exerts neuroprotective effects through attenuation of oxidative stress, as evidenced by increased superoxide dismutase (SOD) and glutathione peroxidase (GSH\u2010Px) activities, alongside reduced malondialdehyde (MDA) levels. These effects are accompanied by modulation of the Slc7a11\u2013Eif4ebp1 signaling axis, suppression of pro\u2010inflammatory cytokines, including IL\u20101\u03b2, IL\u20106, and TNF\u2010\u03b1, and regulation of key molecular pathways. Specifically, GB inhibits JAK\/STAT and TXNIP\/NLRP3 signaling while activating PI3K\/AKT\u2010associated pathways and autophagy. Clinical studies indicate potential improvements in cognitive and functional outcomes. However, adverse events, particularly bleeding, have been reported, especially when GB is co\u2010administered with anticoagulants or nonsteroidal anti\u2010inflammatory drugs. This underscores the importance of careful patient monitoring. The current evidence supports the promising neuroprotective potential of GB in traumatic brain injury. Nevertheless, clinical data remain insufficient to justify routine therapeutic use. Large\u2010scale, well\u2010designed, randomized controlled trials are necessary to confirm efficacy, optimize dosing regimens, and establish long\u2010term safety profiles.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202502901","type":"journal-article","created":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T18:13:28Z","timestamp":1777918408000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["<i>Ginkgo biloba<\/i>\n                    as a Promising Candidate for Traumatic Brain Injury: Insights From Preclinical and Clinical Studies"],"prefix":"10.1002","volume":"23","author":[{"given":"Jilan A.","family":"Nazeam","sequence":"first","affiliation":[{"name":"Pharmacognosy Department, Natural Products Unit, Center of Excellence, Faculty of Pharmacy, October 6 University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omnia","family":"Mahmoud","sequence":"additional","affiliation":[{"name":"Pharmacognosy Department, Natural Products Unit, Center of Excellence, Faculty of Pharmacy, October 6 University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amira","family":"Saad","sequence":"additional","affiliation":[{"name":"Pharmacognosy Department, Natural Products Unit, Center of Excellence, Faculty of Pharmacy, October 6 University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amira","family":"Hassan","sequence":"additional","affiliation":[{"name":"Pharmacognosy Department, Natural Products Unit, Center of Excellence, Faculty of Pharmacy, October 6 University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omnia","family":"Saleh","sequence":"additional","affiliation":[{"name":"Pharmacognosy Department, Natural Products Unit, Center of Excellence, Faculty of Pharmacy, October 6 University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amira","family":"Alaaeldein","sequence":"additional","affiliation":[{"name":"Pharmacognosy Department, Natural Products Unit, Center of Excellence, Faculty of Pharmacy, October 6 University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ethar","family":"Ali","sequence":"additional","affiliation":[{"name":"Pharmacognosy Department, Natural Products Unit, Center of Excellence, Faculty of Pharmacy, October 6 University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Ezzat","sequence":"additional","affiliation":[{"name":"Pharmacognosy Department, Natural Products Unit, Center of Excellence, Faculty of Pharmacy, October 6 University Cairo 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