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As aging significantly alters gut structure and function, protective effect of SREP\u20101 was investigated using a\n                    <jats:sc>d<\/jats:sc>\n                    \u2010galactose\u2010induced aging mouse model. SREP\u20101 administration reversed D\u2010galactose\u2010induced body weight loss and colon damage, as evidenced by improved histopathology. SREP\u20101 mitigated weight loss and colon damage, enhanced the activities of antioxidants (SOD, GSH\u2010Px, and CAT), and reduced the level of MDA. It decreased proinflammatory cytokines (TNF\u2010\u03b1, IL\u20101\u03b2, and IL\u20106) and elevated IL\u201010 in colon tissue, while boosting serum immunoglobulins (IgG and IgM). Crucially, these effects were abolished by antibiotic pretreatment, highlighting the role of gut microbiota in SREP\u20101 bioactivity. This role was further confirmed through fecal microbiota transplantation (FMT) and fecal supernatant transplantation (FST) experiments. Based on 16S rRNA sequencing, SREP\u20101 restored gut microbial diversity, increased beneficial genera (e.g.,\n                    <jats:italic>Faecalibacterium<\/jats:italic>\n                    ,\n                    <jats:italic>Akkermansia<\/jats:italic>\n                    ,\n                    <jats:italic>Lactobacillus<\/jats:italic>\n                    , and\n                    <jats:italic>Bacteroides<\/jats:italic>\n                    ), and decreased harmful bacteria (e.g.,\n                    <jats:italic>Escherichia\u2010Shigella<\/jats:italic>\n                    and\n                    <jats:italic>Collinsella<\/jats:italic>\n                    ). Furthermore, short\u2010chain fatty acids (SCFAs) levels were elevated in the SREP\u20101 group, which might regulate GPCRs\/NF\u2010\u03baB\/Nrf2 signaling pathways and exert biological activity. This study revealed the potential of SREP\u20101 to alleviate aging\u2010related intestinal dysfunction and underscored the crucial role of gut microbiota in mediating these effects.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202502918","type":"journal-article","created":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T18:41:03Z","timestamp":1762800063000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Alleviative Effect of\n                    <i>Stropharia rugosoannulata<\/i>\n                    Exopolysaccharide on\n                    <scp>d<\/scp>\n                    \u2010Galactose\u2010Induced Gut Inflammation and Oxidative Stress by Modulating Gut Microbiota"],"prefix":"10.1002","volume":"23","author":[{"given":"Chenxing","family":"Zhao","sequence":"first","affiliation":[{"name":"College of Food Science and Engineering, Yangzhou University  Yangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song","family":"Ming","sequence":"additional","affiliation":[{"name":"Jiangsu Zhongnongke Food Engineering Co. Ltd.  Suqian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Jiangsu Zhongnongke Food Engineering Co. Ltd.  Suqian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiantian","family":"Huang","sequence":"additional","affiliation":[{"name":"Jiangsu Alphay Bio\u2010Technology Co. Ltd.  Nantong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuguang","family":"Du","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Biochemical Engineering and Key Laboratory of Biopharmaceutical Production &amp; Formulation Engineering, PLA, Institute of Process Engineering, Chinese Academy of Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Food Science and Engineering, Yangzhou University  Yangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9521-2932","authenticated-orcid":false,"given":"Shuai","family":"Zong","sequence":"additional","affiliation":[{"name":"College of Food Science and Engineering, Yangzhou University  Yangzhou 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