{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T07:02:36Z","timestamp":1775890956149,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T00:00:00Z","timestamp":1770595200000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100005230","name":"Natural Science Foundation of Chongqing Municipality","doi-asserted-by":"publisher","award":["CSTB2024NSCQ\u2010MSX0319"],"award-info":[{"award-number":["CSTB2024NSCQ\u2010MSX0319"]}],"id":[{"id":"10.13039\/501100005230","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    To examine the blood components of\n                    <jats:italic>Swertia davidii<\/jats:italic>\n                    Franch. (SDF) and its effects on acute liver injury (ALI) in mice, ultra\u2010performance liquid chromatography with quadrupole time\u2010of\u2010flight mass spectrometry technology was used to analyze the blood of rats after oral SDF extract administration. Potential targets of blood components for improving ALI were screened using Pharmmapper Server, Swiss Target Prediction, and Genecards databases. The STRING 12.0 database and Cytoscape 3.7.2 software assisted in constructing and analyzing the protein\u2010protein interaction network, while the Metascape database facilitated Gene Ontology and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis. Cytoscape 3.7.2 was used to construct and analyze networks to identify key targets of SDF blood components in improving ALI. The molecular docking of blood components with core targets was carried out using Schr\u00f6dinger Maestro 11.1 software. Based on KEGG pathway analysis results, PI3K\/AKT\/NF\u2010\u03baB signaling pathways were selected for experimental verification. Eight blood components, including loganin, gentiopicroside, and oleanolic acid, were detected in serum samples of rats after oral administration. These blood components may influence CDK2, EGFR, and MAPK1, altering PI3K\/AKT\/NF\u2010\u03baB pathways to aid liver injury recovery in mice. SDF showed superior liver protection, likely by activating these pathways. This study provides references for the development of hepatoprotective products and clinical applications of SDF.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202502932","type":"journal-article","created":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T20:36:06Z","timestamp":1770669366000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Investigating the Mechanism of\n                    <i>Swertia davidii<\/i>\n                    Franch. in Treating Acute Liver Injury by Integrating Network Pharmacology"],"prefix":"10.1002","volume":"23","author":[{"given":"Senyao","family":"Cui","sequence":"first","affiliation":[{"name":"School of Pharmacy Chongqing Three Gorges Medical College  Chongqing China"},{"name":"College of Agronomy and Biotechnology Yunnan Agricultural University  Kunming China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunyu","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Pharmacy Chongqing Three Gorges Medical College  Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Xiong","sequence":"additional","affiliation":[{"name":"School of Pharmacy Chongqing Three Gorges Medical College  Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ce","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Pharmacy Chongqing Three Gorges Medical College  Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8797-1413","authenticated-orcid":false,"given":"Wenxiang","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Pharmacy Chongqing Three Gorges Medical College  Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,9]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10238\u2010024\u201001545\u20103"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00063\u2010020\u201000707\u2010x"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.4103\/sjg.sjg_62_24"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/HC9.0000000000000352"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2024.1357468"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/07853890.2024.2438833"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419\u2010023\u201006268\u2010z"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00011\u2010025\u201002026\u20103"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22136921"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.4240\/wjgs.v13.i11.1448"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijms.106360"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11033\u2010024\u201009806\u2010w"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/10286020.2023.2190520"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/10799893.2020.1808675"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12092762"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.2147\/JIR.S369176"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2022.109036"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.2c00195"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines13020393"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.17108"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2019.112361"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41401\u2010020\u201000597\u2010x"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00210\u2010024\u201003712\u20105"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010025\u201093998\u2010z"}],"container-title":["Chemistry &amp; 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