{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T12:46:55Z","timestamp":1775998015831,"version":"3.50.1"},"reference-count":64,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T00:00:00Z","timestamp":1772409600000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    This study investigates the antidepressant potential of a pyrogallol\u2010enriched fraction of\n                    <jats:italic>Emblica officinalis<\/jats:italic>\n                    Gaertn. fruit (PEFEO) in a chronic unpredictable mild stress (CUMS) model of depression in mice, supported by in silico and in vivo evaluations. In vivo studies were conducted with PEFEO (100 and 200\u00a0mg\/kg, p.o.) and fluoxetine (20\u00a0mg\/kg, p.o.) as a standard. Behavioural assessments, including forced swim, Y\u2010maze, open field, and sucrose preference tests, demonstrated the antidepressant effects of PEFEO. Serum pro\u2010inflammatory cytokines (IL\u20101\u03b2, TNF\u2010\u03b1, IL\u20106) were quantified using ELISA, revealing significant reductions following PEFEO treatment. In silico ADMET profiling indicated favourable pharmacokinetic properties of pyrogallol. Network pharmacology suggested involvement of the PI3K signalling pathway in mediating its antidepressant effect, further supported by molecular docking and dynamic simulations with key target genes (NFKB1, CHRM1, CCNE1). Collectively, the findings suggest that PEFEO mitigates depression by modulating behavioural responses and suppressing inflammatory mediators, potentially via PI3K\u2013AKT pathway regulation. This integrative approach underscores pyrogallol as a promising phytoconstituent for the management of depression with associated anti\u2010inflammatory effects.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202502935","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T17:00:00Z","timestamp":1772989200000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<i>Emblica officinalis<\/i>\n                    Fraction Mitigates Depression via PI3K\u2010AKT Pathway: A Pharmacological Study"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-8095-2934","authenticated-orcid":false,"given":"Amartya","family":"Sen","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Technology, School of Health &amp; Medical Sciences Adamas University  Kolkata India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4796-6016","authenticated-orcid":false,"given":"Sourav","family":"Ghosh","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Technology, School of Health &amp; Medical Sciences Adamas University  Kolkata India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-5323-6039","authenticated-orcid":false,"given":"Monosiz","family":"Rahaman","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Technology, School of Health &amp; Medical Sciences Adamas University  Kolkata India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7468-1131","authenticated-orcid":false,"given":"Sheikh","family":"Murtuja","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Technology, School of Health &amp; Medical Sciences Adamas University  Kolkata India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8242-4541","authenticated-orcid":false,"given":"Bhupendra","family":"Prajapati","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, Parul Institute of Pharmacy, Faculty of Pharmacy Parul University  Vadodara India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8442-801X","authenticated-orcid":false,"given":"Biswajit","family":"Basu","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Technology, School of Health &amp; Medical Sciences Adamas University  Kolkata India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,3,2]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2023.175801"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1192\/j.eurpsy.2024.1785"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S30919"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-38013-7"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.34133\/research.0537"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2215-0366(18)30511-X"},{"issue":"15","key":"e_1_2_12_8_1","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1001\/jama.2017.3826","article-title":"Depression Is the Leading Cause of Disability Around the World","volume":"317","author":"Friedrich M. 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