{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T16:59:42Z","timestamp":1785085182630,"version":"3.55.0"},"reference-count":33,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T00:00:00Z","timestamp":1779321600000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Liver fibrosis, a major consequence of chronic liver disease, lacks effective antifibrotic therapies.\n                    <jats:italic>Scabiosa comosa<\/jats:italic>\n                    Fisch. ex Roem. et Schult. (Scabiosa), a traditional Mongolian medicinal plant, has demonstrated hepatoprotective properties; however, its underlying mechanisms remain unclear. The antifibrotic effects of Scabiosa inflorescences and foliage were evaluated in a CCl\n                    <jats:sub>4<\/jats:sub>\n                    \u2010induced murine model of liver fibrosis. Histological staining, serum biomarker analysis, ultra\u2010high\u2010performance liquid chromatography\u2013mass spectrometry profiling, and network pharmacology were employed to assess therapeutic efficacy and to identify bioactive compounds and their potential targets. Key genes and proteins were validated by quantitative reverse transcription polymerase chain reaction and Western blotting. Scabiosa treatment significantly improved liver histopathology, reduced collagen deposition, and decreased the liver\u2010to\u2010body weight ratio. Serum alanine aminotransferase, aspartate aminotransferase, hyaluronic acid, procollagen type III, laminin, and type IV collagen levels were markedly reduced, indicating protection against hepatocellular injury and fibrogenesis. Chemical profiling revealed that multiple bioactive compounds from Scabiosa entered the systemic circulation. Network pharmacology analysis identified core targets, including CD44, c\u2010JUN, OPN, and STAT3, which were downregulated following treatment. Pathway enrichment analysis suggested the involvement of the c\u2010Jun and JAK\/STAT signaling pathways in mediating the antifibrotic effects. Scabiosa inflorescences and foliage effectively attenuated liver fibrosis through multicomponent, multitarget actions, primarily by modulating the c\u2010Jun and JAK\/STAT pathways. These findings provide mechanistic evidence supporting its traditional use and its potential as a therapeutic candidate for chronic liver disease.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202502946","type":"journal-article","created":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T17:15:46Z","timestamp":1779383746000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Scabiosa Inflorescence and Foliage Alleviate Liver Fibrosis via Suppression of c\u2010Jun and JAK\/STAT Signaling Pathways"],"prefix":"10.1002","volume":"23","author":[{"given":"Zhiqiang","family":"Han","sequence":"first","affiliation":[{"name":"Institute of Clinical Pharmacology of Traditional Mongolian Medicine Affiliated Hospital of Inner Mongolia Minzu University  Tongliao City China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi","family":"Liu","sequence":"additional","affiliation":[{"name":"Mongolian Medicine Combines Respiratory and Critical Care Medicine Affiliated Hospital of Inner Mongolia Minzu University  Tongliao City China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adi","family":"Ya","sequence":"additional","affiliation":[{"name":"Institute of Clinical Pharmacology of Traditional Mongolian Medicine Affiliated Hospital of Inner Mongolia Minzu University  Tongliao City China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bian","family":"Tana","sequence":"additional","affiliation":[{"name":"Department of Mongolian Medicine Preparations Affiliated Hospital of Inner Mongolia Minzu University  Tongliao City China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongmei","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Mongolian Medicine Preparations Affiliated Hospital of Inner Mongolia Minzu University  Tongliao City China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Batu","family":"Deligen","sequence":"additional","affiliation":[{"name":"Institute of Clinical Pharmacology of Traditional Mongolian Medicine Affiliated Hospital of Inner Mongolia Minzu University  Tongliao City China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,21]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v22.i48.10512"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2018.09.014"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.32239"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2022.114448"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.32163"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2018.09.002"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joim.2020.03.001"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2023.117516"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.205559"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2023.117656"},{"issue":"4","key":"e_1_2_13_12_1","first-page":"110","article-title":"Scabiosa Genus: A Rich Source of Bioactive Metabolites","volume":"5","author":"Pinto D.","year":"2018","journal-title":"Medicines (Basel)"},{"key":"e_1_2_13_13_1","unstructured":"China PCotPsRo: Pharmacopoeia of the People's Republic of China: Mongolian Medicine Volume. 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Y.","year":"2022","journal-title":"Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-81399-x"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms262010139"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.23567"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2023.115740"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.390506"},{"issue":"3","key":"e_1_2_13_21_1","first-page":"497","article-title":"Cypermethrin Induced Liver Oxidative DNA Damage via the JNK\/c\u2010Jun Pathway]","volume":"52","author":"Ha M.","year":"2023","journal-title":"Wei Sheng Yan Jiu = Journal of Hygiene Research"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202003721"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom13010119"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.2741\/3886"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2024.09.029"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2024.1336102"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.3390\/biology14040428"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2023.122232"},{"key":"e_1_2_13_29_1","article-title":"CD44\u2010Targeted pH\u2010Responsive Nanoenzyme\u2010Liposome Complexes Co\u2010Delivering Ceria Nanozymes and Cryptotanshinone To Alleviate Liver Fibrosis","author":"Liu K.","year":"2026","journal-title":"Molecular pharmaceutics"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-023-02826-6"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aohep.2020.06.010"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.8502"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.21037\/apm.2020.02.29"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-020-01251-y"}],"container-title":["Chemistry &amp; Biodiversity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbdv.202502946","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cbdv.202502946","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbdv.202502946","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T16:00:41Z","timestamp":1785081641000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cbdv.202502946"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":33,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1002\/cbdv.202502946"],"URL":"https:\/\/doi.org\/10.1002\/cbdv.202502946","archive":["Portico"],"relation":{},"ISSN":["1612-1872","1612-1880"],"issn-type":[{"value":"1612-1872","type":"print"},{"value":"1612-1880","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"2025-09-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e02946"}}