{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T12:45:25Z","timestamp":1775997925223,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T00:00:00Z","timestamp":1773878400000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    In this study, biocompounds from\n                    <jats:italic>Annona muricata<\/jats:italic>\n                    L. leaves were ultrasound\u2010assisted extracted and incorporated into an acne\u2010reducing gel product. The total polyphenol content of the extract was 104.794\u00a0mg GAE\/g dry matter when using 90% ethanol at 60\u00b0C for 20 min, with a material\u2010to\u2010solvent ratio of 1:50. The extract exhibited strong antibacterial activity against\n                    <jats:italic>Pseudomonas aeruginosa<\/jats:italic>\n                    and\n                    <jats:italic>Cutibacterium acnes<\/jats:italic>\n                    , with inhibition zones of 19.0 and 20.0\u00a0mm, respectively. The antioxidant capacity of the extract, evaluated via the DPPH assay, yielded an IC\n                    <jats:sub>50<\/jats:sub>\n                    value of 21.63 \u00b1 0.64\u00a0\u00b5g\/mL, indicating moderate activity compared to ascorbic acid (IC\n                    <jats:sub>50<\/jats:sub>\n                    of 6.51\u00a0\u00b5g\/mL). Based on this result, an acne\u2010reducing gel containing the leaves extract was formulated. The product exhibited appropriate pH (5.56), viscosity (8980 cP), and good antibacterial activity in the gel product (inhibition zones of 25.0\u00a0mm for\n                    <jats:italic>P. aeruginosa<\/jats:italic>\n                    and 4.7\u00a0mm for\n                    <jats:italic>C. acnes<\/jats:italic>\n                    ) with high stability and safety criteria for cosmetic products. The study demonstrates the potential application of\n                    <jats:italic>A. muricata<\/jats:italic>\n                    L. leaves in the natural cosmetics industry.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202502958","type":"journal-article","created":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T07:14:05Z","timestamp":1773904445000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Development of Polyphenol\u2010Rich Extract from\n                    <i>Annona muricata<\/i>\n                    L. Leaves and Its Application in Acne\u2010Reducing Gels"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-2233-438X","authenticated-orcid":false,"given":"Lu Thi Mong","family":"Thy","sequence":"first","affiliation":[{"name":"Ho Chi Minh City University of Industry and Trade  Ho Chi Minh City Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nguyen Ngoc Thien","family":"Thanh","sequence":"additional","affiliation":[{"name":"Ho Chi Minh City University of Industry and Trade  Ho Chi Minh City Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huynh Khanh","family":"Duy","sequence":"additional","affiliation":[{"name":"Ho Chi Minh City University of Industry and Trade  Ho Chi Minh City Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-3786-9491","authenticated-orcid":false,"given":"Doan Thi Minh","family":"Phuong","sequence":"additional","affiliation":[{"name":"Ho Chi Minh City University of Industry and Trade  Ho Chi Minh City Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nguyen Tien","family":"Dat","sequence":"additional","affiliation":[{"name":"University of Science (HCMUS), Vietnam National University Ho Chi Minh City (VNU\u2010HCM) Ho Chi Minh City Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4393-5183","authenticated-orcid":false,"given":"Nguyen Minh","family":"Dat","sequence":"additional","affiliation":[{"name":"Unila Limited Company  Vinh Long Province Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,3,19]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2494.2009.00494.x"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5154.44785"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.5630"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/su9111969"},{"issue":"2","key":"e_1_2_10_6_1","first-page":"40","article-title":"Antimicrobial Activities and Phytochemical Properties of Annona muricata Leaf","volume":"5","author":"Olugbuyiro J. 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