{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T07:01:47Z","timestamp":1775890907262,"version":"3.50.1"},"reference-count":63,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T00:00:00Z","timestamp":1765152000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T00:00:00Z","timestamp":1765152000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Natural compounds derived from invasive plant species are increasingly recognized as promising sources of bioactive agents for drug discovery and therapeutic applications. This work explored the chemical diversity and biological potential of\n                    <jats:italic>Tithonia diversifolia<\/jats:italic>\n                    flowers (TDF) and leaves (TDL). Sequential extraction was performed using a dichloromethane\/methanol mixture, followed by phytochemical screening. Quantitative analysis revealed that TDF contained higher phenolic and flavonoid levels but lower proanthocyanins compared to TDL. Antioxidant assays (2,2\u2010diphenyl\u20101\u2010picrylhydrazyl, 2,2\u00b4\u2010azino\u2010bis(3\u2010ethylbenzothiazoline)\u20106\u2010sulfonic acid, and ferric reducing antioxidant power) confirmed that TDF exhibited superior radical scavenging potential. Anticancer activity assessments indicated that both extracts showed cytotoxic effects against liver, colon, breast, and lung cancer cells, with minimal toxicity to normal cells. Besides, substantial \u03b1\u2010amylase and \u03b1\u2010glucosidase enzyme inhibition was displayed by TDL (half\u2010maximal inhibitory concentration values of 38.99 \u00b1 1.10\u00a0and 49.62 \u00b1 1.21\u00a0\u00b5g\/mL), compared to TDF (45.26 \u00b1 2.61\u00a0and 50.53 \u00b1 1.82\u00a0\u00b5g\/mL), respectively, and the acarbose standard. Antifungal evaluation demonstrated subtle potency differences, with TDF (800.0\u00a0\u00b5g\/mL) displaying a lower minimum inhibitory concentration than TDL (900.0\u00a0\u00b5g\/mL) at day 13. Collectively, these findings highlight\n                    <jats:italic>T. diversifolia<\/jats:italic>\n                    extracts as multifunctional agents with significant antioxidant, anticancer, antidiabetic, and antifungal potential, supporting their application in pharmaceutical drug development.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202502969","type":"journal-article","created":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T10:04:51Z","timestamp":1765188291000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Bioactive Potential of\n                    <i>Tithonia diversifolia<\/i>\n                    : Phytochemical Profiling and Multifunctional Activities"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8595-2649","authenticated-orcid":false,"given":"Yvan Anderson Tchangoue","family":"Ngandjui","sequence":"first","affiliation":[{"name":"Institute For Nanotechnology and Water Sustainability (iNanoWS), College of Science, Engineering and Technology (CSET) University of South Africa  Florida South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adewale Odunayo","family":"Oladipo","sequence":"additional","affiliation":[{"name":"Department of Life and Consumer Sciences, College of Agriculture and Environmental Sciences (CAES) University of South Africa  Florida South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aubrey Dickson","family":"Chigwada","sequence":"additional","affiliation":[{"name":"Department of Environmental Science, College of Agricultural and Environmental Sciences University of South Africa  Roodepoort South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Memory","family":"Tekere","sequence":"additional","affiliation":[{"name":"Department of Environmental Science, College of Agricultural and Environmental Sciences University of South Africa  Roodepoort South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bathelemy","family":"Ngameni","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy and Pharmaceutical Chemistry, Faculty of Medicine and Biomedical Sciences University of Yaound\u00e9 I  Yaound\u00e9 Cameroon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sogolo Lucky","family":"Lebelo","sequence":"additional","affiliation":[{"name":"Department of Life and Consumer Sciences, College of Agriculture and Environmental Sciences (CAES) University of South Africa  Florida South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Titus Alfred Makudali","family":"Msagati","sequence":"additional","affiliation":[{"name":"Institute For Nanotechnology and Water Sustainability (iNanoWS), College of Science, Engineering and Technology (CSET) University of South Africa  Florida South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,12,8]]},"reference":[{"key":"e_1_2_12_2_1","first-page":"18","article-title":"Why Are Invasive Plants Successful?","volume":"34","author":"Gioria M.","year":"2023","journal-title":"Annual Review of Plant Biology"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoser.2025.101703"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/nph.12388"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1631\/jzus.B2000683"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10904\u2010024\u201003100\u20109"},{"key":"e_1_2_12_7_1","article-title":"Therapeutic Potential of Medicinal Plants and Their Phytoconstituents in Diabetes, Cancer, Infections, Cardiovascular Diseases, Inflammation, and Gastrointestinal Disorders","volume":"13","author":"Ansari P.","year":"2025","journal-title":"Biomed"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/14786419.2020.1729151"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.inoche.2025.114483"},{"key":"e_1_2_12_10_1","first-page":"1705","article-title":"Greenwaylactams A, B and C, the First Group of Sesquiterpene Alkaloids With an Eight\u2010Membered Lactam Ring From Greenwayodendron oliveri","volume":"6","author":"Kemgni M. 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