{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T20:14:41Z","timestamp":1783368881888,"version":"3.54.6"},"reference-count":15,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T00:00:00Z","timestamp":1780617600000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82304659"],"award-info":[{"award-number":["82304659"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC3501700"],"award-info":[{"award-number":["2022YFC3501700"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2026,6]]},"abstract":"ABSTRACT<\/jats:title>\n \n Three new HHDP\u2010bridged macrocyclic polyphenols, designated as Uvangoletin\u20107\u2010O\u20104'',6''\u2010 (\n S<\/jats:italic>\n )\u2010HHDP\u2010\n \u03b2<\/jats:italic>\n \u2010D\u2010glucopyranoside (Penthorumside D,\n 1<\/jats:bold>\n ), Uvangoletin\u20107\u2010O\u20103''\u2010O\u2010galloyl\u20104'',6''\u2010(\n S<\/jats:italic>\n )\u2010HHDP\u2010\n \u03b2<\/jats:italic>\n \u2010D\u2010glucopyranoside (Penthorumside E,\n 2<\/jats:bold>\n ), and, Pinocembrin\u20107\u2010O\u2010{4'',6''\u2010[7''',7''''\u2010(3''',3'''',4''',4''''\u2010tetrahydroxydibenzofurandicarboxyl)]}\u2010\n \u03b2<\/jats:italic>\n \u2010D\u2010glucopyranoside (Penthorumside F,\n 3<\/jats:bold>\n ), along with three known compounds (\n 4\u20106<\/jats:bold>\n ), were isolated from the aerial parts of\n Penthorum chinense<\/jats:italic>\n Pursh. Among them,\n 1<\/jats:bold>\n and\n 2<\/jats:bold>\n are chalcone glycosides, while\n 3<\/jats:bold>\n is a flavanone glycoside. Their structures were elucidated by HR\u2010ESI\u2010MS, NMR spectrum and electronic circular dichroism (ECD), in combination with data from known analogues. The farnesoid X receptor (FXR) binding activities of the isolated compounds were evaluated, using luciferase activities examination. Compounds\n 4<\/jats:bold>\n and\n 6<\/jats:bold>\n exhibited significant FXR activation at 5 \u00b5M (\n p<\/jats:italic>\n \u00a0=\u00a00.003 and 0.014), with luciferase activities increasing by 1.28\u2010 and 1.18\u2010fold compared to the vehicle control, taking GW4064 as positive control. In contrast, other compounds did not show significant agonistic effects (\n p<\/jats:italic>\n \u00a0>\u00a00.05). These findings suggested\n 4<\/jats:bold>\n and\n 6<\/jats:bold>\n exerted promising FXR agonistic effects with potential for development as anti\u2010cholestatic agents.\n <\/jats:p>","DOI":"10.1002\/cbdv.202502975","type":"journal-article","created":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T10:51:15Z","timestamp":1780656675000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Three New HHDP\u2010Bridged Macrocyclic Polyphenols With FXR Agonistic Activity From\n Penthorum chinense<\/i>\n Pursh"],"prefix":"10.1002","volume":"23","author":[{"given":"Yixiao","family":"Lu","sequence":"first","affiliation":[{"name":"School of Pharmacy Shanghai University of Traditional Chinese Medicine Shanghai P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengyao","family":"Lu","sequence":"additional","affiliation":[{"name":"School of Pharmacy Shanghai University of Traditional Chinese Medicine Shanghai P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunxia","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Health Management Wuhan Vocational College of Software and Engineering Wuhan P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyan","family":"Zhuang","sequence":"additional","affiliation":[{"name":"School of Pharmacy Shanghai University of Traditional Chinese Medicine Shanghai P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingyu","family":"Ba","sequence":"additional","affiliation":[{"name":"School of Pharmacy Shanghai University of Traditional Chinese Medicine Shanghai P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Du","sequence":"additional","affiliation":[{"name":"Amway (Shanghai) Innovation & Science Co., Ltd Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Pharmacy Shanghai University of Traditional Chinese Medicine Shanghai P. R. China"},{"name":"Amway (Shanghai) Innovation & Science Co., Ltd Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wansheng","family":"Chen","sequence":"additional","affiliation":[{"name":"Center of Chinese Traditional Medicine Resources and Biotechnology Institute of Chinese Materia Medica Shanghai University of Traditional Chinese Medicine Shanghai P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doudou","family":"Huang","sequence":"additional","affiliation":[{"name":"School of Pharmacy Shanghai University of Traditional Chinese Medicine Shanghai P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4004-8028","authenticated-orcid":false,"given":"Lianna","family":"Sun","sequence":"additional","affiliation":[{"name":"School of Pharmacy Shanghai University of Traditional Chinese Medicine Shanghai P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,5]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"889","article-title":"Herbal Textual Research, Chemical Components and Pharmacological Effects of Penthorum chinense","volume":"23","author":"Yuan X.","year":"2023","journal-title":"Evaluation and Analysis of Drug\u2010Use in Hospitals of China"},{"key":"e_1_2_9_3_1","first-page":"121","article-title":"Advances in Studies on Chemical Composition and Pharmacological Activity of Penthorum chinense Pursh","volume":"51","author":"L\u00fc J.","year":"2024","journal-title":"Journal of Liaoning University (Natural Science Edition)"},{"key":"e_1_2_9_4_1","volume-title":"Study on Active Ingredients From Penthorum chinense Pursh","author":"Sun Z.","year":"2016"},{"key":"e_1_2_9_5_1","first-page":"31","article-title":"Study on Flavonoids of Penthorum chinense","volume":"48","author":"Zhang X.","year":"2017","journal-title":"Chinese Traditional and Herbal Drugs"},{"key":"e_1_2_9_6_1","volume-title":"Study on Quality Standard Improvement of Penthorum chinense and Its Preparation & Preparation Technology of Macrocyclic Polyphenols","author":"Shi P.","year":"2020"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265\u2010016\u20100616\u2010x"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1509840"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0305\u20101978(82)90033\u20103"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/np990396w"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules190811045"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/14786419.2024.2426211"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.53.339"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/10286020500246667"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960\u2010894X(03)00584\u20105"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.202500068"}],"container-title":["Chemistry & Biodiversity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbdv.202502975","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cbdv.202502975","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbdv.202502975","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T19:20:56Z","timestamp":1783365656000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cbdv.202502975"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":15,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1002\/cbdv.202502975"],"URL":"https:\/\/doi.org\/10.1002\/cbdv.202502975","archive":["Portico"],"relation":{},"ISSN":["1612-1872","1612-1880"],"issn-type":[{"value":"1612-1872","type":"print"},{"value":"1612-1880","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"2025-09-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e02975"}}