{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T16:59:38Z","timestamp":1785085178694,"version":"3.55.0"},"reference-count":38,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,24]],"date-time":"2026-05-24T00:00:00Z","timestamp":1779580800000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Pharbitis nil<\/jats:italic>\n                    (L.) Choisy is a traditional medicinal plant exhibiting broad\u2010spectrum pharmacological effects, including anti\u2010cancer, renoprotective, and laxative effects; insecticidal activity; and antifungal, anti\u2010inflammatory, antioxidant, neuroprotective, and hepatoprotective actions. In this study, 11 compounds were isolated from the seeds of the plant and structurally characterized. These included one novel benzodioxane derivative named pharbitan A (\n                    <jats:bold>2<\/jats:bold>\n                    ), one phenolic compound (\n                    <jats:bold>1<\/jats:bold>\n                    ), and nine caffeic acid derivatives (\n                    <jats:bold>3\u201311<\/jats:bold>\n                    ). Bioactivity assays demonstrated that both fractions and isolated compounds from\n                    <jats:italic>Pharbitis nil<\/jats:italic>\n                    seeds significantly inhibited interleukin\u20104 and histamine secretion in phorbol 12\u2010myristate 13\u2010acetate\/ionomycin\u2010induced RBL\u20102H3 cells, as well as suppressed interlekin\u20101\n                    <jats:italic>\u03b2<\/jats:italic>\n                    production by lipopolysaccharide\u2010stimulated RAW 264.7 macrophages. Notably, compounds\n                    <jats:bold>2<\/jats:bold>\n                    and\n                    <jats:bold>7<\/jats:bold>\n                    reduced cyclooxygenase\u20102 expression and modulated mitogen\u2010activated protein kinase signaling pathways through inhibition of p38 MAPK and ERK phosphorylation. These results suggest that\n                    <jats:italic>Pharbitis nil<\/jats:italic>\n                    seeds and their constituents have notable anti\u2010allergic and anti\u2010inflammatory activities, highlighting their potential as natural therapeutic agents.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202502992","type":"journal-article","created":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T05:49:21Z","timestamp":1779688161000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Anti\u2010Allergic and Anti\u2010Inflammatory Activities of a New Benzodioxane Derivative and Phenolic Compounds From\n                    <i>Pharbitis nil<\/i>\n                    Seeds"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2102-9016","authenticated-orcid":false,"given":"Do Thi","family":"Ha","sequence":"first","affiliation":[{"name":"National Institute of Medical Materials (NIMM)  Hanoi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nguyen Thi Kim","family":"Oanh","sequence":"additional","affiliation":[{"name":"National Institute of Medical Materials (NIMM)  Hanoi Vietnam"},{"name":"Thai Binh University of Medicine and Pharmacy  Hung Yen Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nguyen Manh","family":"Khoa","sequence":"additional","affiliation":[{"name":"National Institute of Medical Materials (NIMM)  Hanoi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tran Thi","family":"Hien","sequence":"additional","affiliation":[{"name":"Thai Binh University of Medicine and Pharmacy  Hung Yen Vietnam"},{"name":"Department of Microbiology Immunology and Glycobiology Institute of Laboratory Medicine Lund University  Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nguyen Thi","family":"Thu","sequence":"additional","affiliation":[{"name":"National Institute of Medical Materials (NIMM)  Hanoi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vu Huong","family":"Thuy","sequence":"additional","affiliation":[{"name":"Traphaco Joint Stock Company  Hanoi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nguyen Huy","family":"Van","sequence":"additional","affiliation":[{"name":"Traphaco Joint Stock Company  Hanoi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tran Quang","family":"Luc","sequence":"additional","affiliation":[{"name":"Traphaco Joint Stock Company  Hanoi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nguyen Thi Vinh","family":"Hue","sequence":"additional","affiliation":[{"name":"Traphaco Joint Stock Company  Hanoi Vietnam"},{"name":"Faculty of Pharmacy Dainam University  Ha Dong Hanoi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,24]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"3","volume-title":"Multidisciplinary Approaches to Allergies","author":"Gao Z. 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