{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T13:13:18Z","timestamp":1787317998694,"version":"build-2736575974"},"reference-count":53,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Psoriasis is a chronic inflammatory skin disorder in which existing topical and systemic therapies are often limited by adverse effects and poor patient compliance. This study aimed to develop a curcumin\u2010loaded solid lipid nanoparticle CUR\u2010SLN (curcumin solid lipid nanoparticles) loaded nanogel to enhance topical delivery and therapeutic efficacy. CUR\u2010SLNs were prepared using a solvent diffusion method and characterized for particle size, polydispersity index (PDI), zeta potential, entrapment efficiency, and morphology. The optimized nanoparticles (133.90\u00a0\u00b1\u00a02.45\u00a0nm; PDI 0.325\u00a0\u00b1\u00a00.21; entrapment efficiency 89.50%\u00a0\u00b1\u00a04.52%) were incorporated into a Carbopol\u2010based gel to formulate the CUR\u2010SLN nanogel. The nanogel was evaluated for appearance, viscosity, pH, and texture profile, along with in vitro drug release, ex vivo skin permeation, drug retention, and stability. Compared with a conventional curcumin gel, the CUR\u2010SLN\u2010loaded nanogel demonstrated sustained drug release over 48\u00a0h and significantly enhanced skin permeation and retention. In vivo studies in a psoriasis\u2010induced mouse model showed a marked reduction in Psoriasis Area and Severity Index scores and significant downregulation of key pro\u2010inflammatory cytokines (interferon\u2010\u03b1 [IFN\u2010\u03b1], IL\u201023, interleukin\u201017 [IL\u201017], tumor necrosis factor\u2010\u03b1 [TNF\u2010\u03b1]) (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a00.001). Histological evaluation further confirmed restoration of normal skin structure in treated animals. Overall, the CUR\u2010SLN\u2010loaded nanogel represents a promising and safer topical therapeutic strategy for psoriasis, supporting its potential for further clinical development.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202503014","type":"journal-article","created":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T13:12:54Z","timestamp":1770124374000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Enhanced Anti\u2010Psoriasis Efficacy of Curcumin via Optimized Nanostructured Lipid Carrier\u2010Embedded Nanogel System"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3821-1500","authenticated-orcid":false,"given":"Vinay","family":"Kumar","sequence":"first","affiliation":[{"name":"KIET Group of Institutions (KIET) Delhi\u2010NCR Ghaziabad Uttar Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kandasamy","family":"Nagarajan","sequence":"additional","affiliation":[{"name":"KIET Group of Institutions (KIET) Delhi\u2010NCR Ghaziabad Uttar Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanhaiya","family":"Singh","sequence":"additional","affiliation":[{"name":"KIET Group of Institutions (KIET) Delhi\u2010NCR Ghaziabad Uttar Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-7209-1163","authenticated-orcid":false,"given":"Gauri","family":"Goyal","sequence":"additional","affiliation":[{"name":"KIET Group of Institutions (KIET) Delhi\u2010NCR Ghaziabad Uttar Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamal","family":"Shah","sequence":"additional","affiliation":[{"name":"Institute of Pharmaceutical Research (IPR) GLA University  Mathura Uttar Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Perwez","family":"Alam","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy College of Pharmacy King Saud University  Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3440-1884","authenticated-orcid":false,"given":"Hitesh Kumar","family":"Dewangan","sequence":"additional","affiliation":[{"name":"University Institute of Pharma Sciences Chandigarh University  Mohali Punjab India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Lakshmi","sequence":"additional","affiliation":[{"name":"KIET Group of Institutions (KIET) Delhi\u2010NCR Ghaziabad Uttar Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,3]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.9b15668"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.3109\/08923973.2013.862542"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2025.114064"},{"issue":"8","key":"e_1_2_12_5_1","first-page":"2033","article-title":"Nanovaccine for Immunotherapy and Reduced Hepatitis B Virus in Humanized Mice","volume":"46","author":"Dewangan H. 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