{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T12:49:52Z","timestamp":1778676592852,"version":"3.51.4"},"reference-count":65,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T00:00:00Z","timestamp":1764892800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T00:00:00Z","timestamp":1764892800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Depression being one of the most common psychiatric comorbidities in people with epilepsy. Based on the potent antidepressant and anticonvulsant activities of thiazolidinone moieties, we designed and synthesized a novel series of 5\u2010arylidenethiazolidine\u20102,4\u2010dione derivatives (\n                    <jats:bold>11a<\/jats:bold>\n                    \u2013\n                    <jats:bold>h<\/jats:bold>\n                    ) and (\n                    <jats:bold>12a<\/jats:bold>\n                    \u2013\n                    <jats:bold>h<\/jats:bold>\n                    ), and investigated their in vivo anticonvulsant activity using the pentylenetetrazol\u2010induced model (PTZ), along with their antidepressant activity assessed by the forced swim test (FST) and tail suspension test (TST) in mice. The structures of the synthesized compounds were established through\n                    <jats:sup>1<\/jats:sup>\n                    H NMR,\n                    <jats:sup>13<\/jats:sup>\n                    C NMR, and LC\u2013MS analysis. The study revealed that compounds\n                    <jats:bold>11e<\/jats:bold>\n                    ,\n                    <jats:bold>12e<\/jats:bold>\n                    , and\n                    <jats:bold>12g<\/jats:bold>\n                    exhibited potent antidepressant activity, which reduces immobility time by approximately 50% at 20\u00a0mg\/kg. In addition, compounds\n                    <jats:bold>11c<\/jats:bold>\n                    ,\n                    <jats:bold>11e<\/jats:bold>\n                    ,\n                    <jats:bold>11g<\/jats:bold>\n                    ,\n                    <jats:bold>12c<\/jats:bold>\n                    , and\n                    <jats:bold>12g<\/jats:bold>\n                    were identified as potent anticonvulsants, reducing post\u2010convulsion effects such as duration of convulsion, jerking, and Straub's tail by more than 60% at 20\u00a0mg\/kg. Furthermore, key ADMET features were calculated in silico for the most active molecules to determine their pharmacokinetic properties. Molecular docking and MD simulation confirms their binding interactions to target proteins. Based on these findings, the compounds\n                    <jats:bold>11c<\/jats:bold>\n                    ,\n                    <jats:bold>11e<\/jats:bold>\n                    ,\n                    <jats:bold>11g<\/jats:bold>\n                    ,\n                    <jats:bold>12c<\/jats:bold>\n                    ,\n                    <jats:bold>12e<\/jats:bold>\n                    , and\n                    <jats:bold>12g<\/jats:bold>\n                    are promising lead candidates for the development of more effective anticonvulsant and antidepressant agents.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202503016","type":"journal-article","created":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T16:25:43Z","timestamp":1764951943000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Discovery of Novel 5\u2010Arylidenethiazolidine\u20102,4\u2010dione Derivatives as Antidepressant and Antiepileptic Agents With In Silico ADMET and Molecular Docking Studies"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-9378-5213","authenticated-orcid":false,"given":"Paduvalamarahalli Mariswamy","family":"BharathKumar","sequence":"first","affiliation":[{"name":"Department of Studies in Chemistry University of Mysore  Mysuru India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8131-2118","authenticated-orcid":false,"given":"Javarappa","family":"Rangaswamy","sequence":"additional","affiliation":[{"name":"Department of Chemistry Poornaprajna College Shri Adamaru Matha Education Council Mangalore University  Udupi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ankanashettypura Chikkachannanjaiah","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Studies in Chemistry University of Mysore  Mysuru India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Madalambika","family":"Mahadevappa","sequence":"additional","affiliation":[{"name":"Department of Studies in Chemistry University of Mysore  Mysuru India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mallappa","family":"Salavadi","sequence":"additional","affiliation":[{"name":"Department of Pharmacology BVVS Hanagal Shri Kumareshwar College of Pharmacy  Bagalkot India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9303-1193","authenticated-orcid":false,"given":"Nagaraja","family":"Naik","sequence":"additional","affiliation":[{"name":"Department of Studies in Chemistry University of Mysore  Mysuru 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