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However, the impact of cultivation conditions on their therapeutic potential remains poorly understood. This study compared the phytochemical profiles and bioactivities of hydroponically cultivated and wild\u2010collected material of these species from Lugazi Diocese, Uganda. Extracts were prepared using ethanol, methanol, and water, and analyzed by thin\u2010layer chromatography (TLC), high\u2010performance liquid chromatography (HPLC\u2010UV), headspace gas chromatography\u2013mass spectrometry (HS\u2010GC\u2013MS), and liquid chromatography\u2013tandem mass spectrometry (LC\u2013MS\/MS). TLC and HPLC\u2010UV indicated terpenoids, flavonoids, and steroids, while HS\u2010GC\u2013MS revealed predominantly monoterpenes and sesquiterpenes. LC\u2013MS\/MS annotated flavonoids, including quercetin\u20103\u2010O\u2010glucuronoside, kaempferol\u20103\u2010O\u2010rutinoside, and kaempferol, as well as triterpenoids such as asiatic acid and katononic acid. Antibacterial activity was evaluated against\n                    <jats:italic>Bacillus subtilis<\/jats:italic>\n                    ,\n                    <jats:italic>Escherichia coli<\/jats:italic>\n                    ,\n                    <jats:italic>Pseudomonas fluorescens<\/jats:italic>\n                    , and\n                    <jats:italic>Saccharomyces cerevisiae<\/jats:italic>\n                    using the agar well diffusion method. Anti\u2010inflammatory effects were assessed by IL\u20106 and IL\u20108 secretion, and cytotoxicity by MTT assay. Ethanol and methanol extracts exhibited moderate antibacterial activity, while aqueous extracts of wild\n                    <jats:italic>C. asiatica<\/jats:italic>\n                    and hydroponic\n                    <jats:italic>C. sumatrensis<\/jats:italic>\n                    significantly reduced IL\u20106 secretion. No cytotoxic effects were detected. These findings suggest hydroponic cultivation preserves essential phytochemicals and bioactivities, supporting sustainable production of medicinal plants for therapeutic applications.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202503018","type":"journal-article","created":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T09:42:17Z","timestamp":1768642937000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparative Phytochemical Profiles of Medicinal Plants Used for Wound Treatment: Insights From Wild and Hydroponically Cultivated Species in Lugazi Diocese, Uganda"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6440-3437","authenticated-orcid":false,"given":"Ivan","family":"Kahwa","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Biology, Faculty of Medicine, Institute For Drug Discovery Leipzig University  Leipzig 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Uganda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Kulosa","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Biology, Faculty of Medicine, Institute For Drug Discovery Leipzig University  Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Billig","sequence":"additional","affiliation":[{"name":"Institute of Analytical Chemistry, Faculty of Chemistry Leipzig University  Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Wiesner","sequence":"additional","affiliation":[{"name":"Institute of Analytical Chemistry, Faculty of Chemistry Leipzig University  Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anke","family":"Weisheit","sequence":"additional","affiliation":[{"name":"Pharm\u2010Biotechnology and Traditional Medicine Centre Mbarara University of Science and Technology  Mbarara Uganda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia Harriet","family":"Makumbi","sequence":"additional","affiliation":[{"name":"Lugazi Rural Finance Development Trust, Namagunga  Lugazi Uganda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9","family":"Gerth","sequence":"additional","affiliation":[{"name":"Independent Researcher, Fuerstenweg  Grimma Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonard","family":"Kaysser","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Biology, Faculty of Medicine, Institute For Drug Discovery Leipzig University  Leipzig 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