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(Family\u2010 Meliaceae) has been traditionally used to treat various ailments, including diabetes. The present study aimed to validate the antidiabetic efficacy of\n                    <jats:italic>C. baccifera<\/jats:italic>\n                    using both in vitro and in vivo diabetic models, followed by a mechanistic evaluation. UPLC\u2010Q\u2010ToF\/MS analysis, enzyme inhibition assays, and in silico studies were performed. Cytotoxicity and glucose uptake studies were conducted on MIN6 cell line. qRT\u2012PCR was carried to assess GLUT4 expression in adipocytes. Immunostaining was performed to examine the differential expression of pancreatic cell subtypes. UPLC\u2010Q\u2010ToF\/MS analysis identified 93 compounds, of which 18 were further selected for in silico protein\u2012protein interaction (PPI) network analysis. PPI network and pathway enrichment analyses predicted that the PPARG, AKT1, SIRT1, and FOXO1 genes are key regulators in diabetes. The in vitro enzyme inhibition assay revealed significant inhibition by the 70% hydroethanolic extract. The mechanistic study showed notable upregulation of GLUT4 mRNA expression, which also supports the network analysis algorithm. The in vivo study demonstrated a significant decrease in blood glucose, insulin, and HbA1c levels in the treated model. Immunostaining revealed significant restoration of insulin and myosin expression. These combined results highlight the potential of\n                    <jats:italic>C. baccifera<\/jats:italic>\n                    as a valuable supplement for diabetes management.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202503022","type":"journal-article","created":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T11:28:43Z","timestamp":1767871723000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Integrative Approach to Elucidate the Antidiabetic Efficacy of\n                    <i>Cipadessa baccifera<\/i>\n                    (Roth) Miq.: A Study Based on Metabolomics, Network Pharmacology, and Animal Models"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2722-5555","authenticated-orcid":false,"given":"Dibya Ranjan","family":"Sahoo","sequence":"first","affiliation":[{"name":"Centre of Excellence in Natural Products and Therapeutics, Department of Biotechnology and Bioinformatics Sambalpur University  Sambalpur Odisha India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swaraj Kumar","family":"Babu","sequence":"additional","affiliation":[{"name":"Centre of Excellence in Natural Products and Therapeutics, Department of Biotechnology and Bioinformatics Sambalpur University  Sambalpur Odisha India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhijit","family":"Sahu","sequence":"additional","affiliation":[{"name":"Centre of Excellence in Natural Products and Therapeutics, Department of Biotechnology and Bioinformatics Sambalpur University  Sambalpur Odisha India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Srichandan","family":"Rath","sequence":"additional","affiliation":[{"name":"Centre of Excellence in Natural Products and Therapeutics, Department of Biotechnology and Bioinformatics Sambalpur University  Sambalpur Odisha India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Surjeet","family":"Verma","sequence":"additional","affiliation":[{"name":"Centre of Excellence in Natural Products and Therapeutics, Department of Biotechnology and Bioinformatics Sambalpur University  Sambalpur Odisha India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malayamarutham","family":"Kalyankumarraju","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Central Ayurveda Research Institute  Kolkata India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit Kumar","family":"Dixit","sequence":"additional","affiliation":[{"name":"Department of Pathology, Biochemistry and Microbiology Central Ayurveda Research Institute  Kolkata India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepak","family":"Lamba","sequence":"additional","affiliation":[{"name":"Pharmacology Section Central Council for Research in Ayurvedic Sciences, Ministry of AYUSH  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjaya Kumar","family":"YR","sequence":"additional","affiliation":[{"name":"Central Council for Research in Ayurvedic Sciences Ministry of AYUSH  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rabinarayan","family":"Acharya","sequence":"additional","affiliation":[{"name":"Central Council for Research in Ayurvedic Sciences Ministry of AYUSH  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7044-2427","authenticated-orcid":false,"given":"Pradeep Kumar","family":"Naik","sequence":"additional","affiliation":[{"name":"Centre of Excellence in Natural Products and Therapeutics, Department of Biotechnology and Bioinformatics Sambalpur University  Sambalpur Odisha 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