{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T12:46:44Z","timestamp":1775998004850,"version":"3.50.1"},"reference-count":65,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T00:00:00Z","timestamp":1773360000000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Lead hepatotoxicity was experimentally induced in rats, followed by treatment with antioxidant\u2010rich rosemary (\n                    <jats:italic>Rosmarinus officinalis<\/jats:italic>\n                    ) ethanol extract (REE). Lipid profile parameters, liver function markers, antioxidant enzymes (SOD, GSH, and MDA), free fatty acids, and HMG\u2010CoA reductase levels were evaluated using standard biochemical assay kits and ELISA methods. REE exhibited high phenolic (56.69 \u00b1 0.05 GAE\/g) and flavonoid contents (8.41 \u00b1 0.02\u00a0mg QE\/g), and HPLC analysis identified quercetin,\n                    <jats:italic>p<\/jats:italic>\n                    \u2010coumaric acid, caffeic acid, and rosmarinic acid as major phenolic constituents. Hepatic lead accumulation (2.70 \u00b1 0.32;\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.05) not only caused significant body weight loss but also resulted in dyslipidemia and hyperglycemia, evidenced by elevated serum cholesterol (118 \u00b1 5.69\u00a0mg\/dL) and triglycerides (130 \u00b1 4.34\u00a0mg\/dL). Exposure to PbAc induced hepatotoxicity and oxidative stress, as shown by elevated ALT levels (65 \u00b1 3.75\u00a0U\/L), increased lipid peroxidation, and depletion of antioxidant defenses, especially GSH (17 \u00b1 1.77\u00a0U\/L) (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.05). Treatment with REE or\n                    <jats:italic>trans<\/jats:italic>\n                    \u2010resveratrol (RSV), either alone or in combination with PbAc, significantly attenuated lead\u2010induced toxicity by restoring lipid homeostasis, antioxidant status, liver enzymes, and normal hepatic architecture (\n                    <jats:italic>p<\/jats:italic>\n                    &gt; 0.05\u00a0vs. control). These findings demonstrate the hepatoprotective potential of REE, likely mediated by its antioxidant\u2010rich phytoconstituents.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202503042","type":"journal-article","created":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T09:08:28Z","timestamp":1773392908000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Biochemical Profiling of Lead\u2010Induced Lipid Metabolic Dysfunction and Its Amelioration by Bioactive Compounds From\n                    <i>Rosmarinus officinalis<\/i>\n                    Ethanol Extract"],"prefix":"10.1002","volume":"23","author":[{"given":"Muhammad Naeem","family":"Qaiser","sequence":"first","affiliation":[{"name":"College of Pharmacy University of Sargodha  Sargodha Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kamran","family":"Haider","sequence":"additional","affiliation":[{"name":"College of Pharmacy University of Sargodha  Sargodha Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-7321-3784","authenticated-orcid":false,"given":"Muhammad","family":"Wajid","sequence":"additional","affiliation":[{"name":"Royal Institute of Medical Sciences  Multan Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Imran","family":"Ahmad","sequence":"additional","affiliation":[{"name":"Bakhtawar Amin College of Pharmaceutical Sciences  Multan Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gulzar","family":"Muhammad","sequence":"additional","affiliation":[{"name":"Department of Chemistry Institute of Chemical Sciences Government College University Lahore  Lahore Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aamir","family":"Mushtaq","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences Government College University Lahore  Lahore Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehreen","family":"Ilyas","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences Superior University  Lahore Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asma","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Institute of Molecular Biology and Biotechnology (IMMB) The University of Lahore  Lahore Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rehana","family":"Badar","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences Superior University  Lahore 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