{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T08:01:45Z","timestamp":1785484905909,"version":"3.56.0"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T00:00:00Z","timestamp":1767830400000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2024JJ8194"],"award-info":[{"award-number":["2024JJ8194"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2024JJ5297"],"award-info":[{"award-number":["2024JJ5297"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    One new phenylethanoid glycoside, named bungaside A (\n                    <jats:bold>1<\/jats:bold>\n                    ), along with six known phenylethanoid glycosides (\n                    <jats:bold>2<\/jats:bold>\n                    \u2013\n                    <jats:bold>7<\/jats:bold>\n                    ), were isolated from the dried aerial parts of\n                    <jats:italic>Clerodendrum bungei<\/jats:italic>\n                    Steud. Their structures were elucidated from extensive spectroscopic analysis and hydrolysis. All the isolates were evaluated for their anti\u2010tumor effects against H460, A549, and HepG2 cancer cell lines. Compound\n                    <jats:bold>7<\/jats:bold>\n                    showed moderate activity against all cell lines, with the half\u2010maximal inhibitory concentration (IC\n                    <jats:sub>50<\/jats:sub>\n                    ) values ranging from 2.25 to 13.13 \u00b5M. Meanwhile, compounds\n                    <jats:bold>3<\/jats:bold>\n                    and\n                    <jats:bold>6<\/jats:bold>\n                    displayed weak activities on A549 with the IC\n                    <jats:sub>50<\/jats:sub>\n                    values of 11.61 \u00b1 1.38 and 16.68 \u00b1 1.16 \u00b5M. Compounds\n                    <jats:bold>3<\/jats:bold>\n                    and\n                    <jats:bold>6<\/jats:bold>\n                    displayed moderate activities on H460 with the IC\n                    <jats:sub>50<\/jats:sub>\n                    values of 5.10 \u00b1 0.12 and 7.23 \u00b1 0.65 \u00b5M, respectively. Besides, the preliminary structure\u2010activities relationship showed that the skeleton of phenylethanoid glycosides containing a monosaccharide may have a stronger anticancer effect than their corresponding disaccharides, and the increase in the methylation of the hydroxyl group on the aromatic ring is also an important reason decrease in activity.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202503074","type":"journal-article","created":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T12:22:24Z","timestamp":1767874944000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Phenylethanoid Glycosides From\n                    <i>Clerodendrum bungei<\/i>\n                    and Their Cytotoxic Activities"],"prefix":"10.1002","volume":"23","author":[{"given":"Qiao\u2010Qiao","family":"Chen","sequence":"first","affiliation":[{"name":"TCM and Ethnomedicine Innovation &amp; Development International Laboratory Innovative Materia Medica Research Institute School of Pharmacy Hunan University of Chinese Medicine  Changsha P. R. China"},{"name":"Department of Pharmacy Ruijin\u2010Hainan Hospital Shanghai Jiao Tong University School of Medicine, (Hainan Boao Research Hospital)  Qionghai Hainan P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7445-5428","authenticated-orcid":false,"given":"Xu\u2010Dong","family":"Zhou","sequence":"additional","affiliation":[{"name":"TCM and Ethnomedicine Innovation &amp; Development International Laboratory Innovative Materia Medica Research Institute School of Pharmacy Hunan University of Chinese Medicine  Changsha P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong\u2010Hui","family":"Li","sequence":"additional","affiliation":[{"name":"The First Hospital of Hunan University of Chinese Medicine Hunan University of Chinese Medicine  Changsha P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Tang","sequence":"additional","affiliation":[{"name":"Hunan Provincial Hospital of Integrated Traditional Chinese and Western Medicine Hunan University of Chinese Medicine  Changsha P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi","family":"Wang","sequence":"additional","affiliation":[{"name":"TCM and Ethnomedicine Innovation &amp; Development International Laboratory Innovative Materia Medica Research Institute School of Pharmacy Hunan University of Chinese Medicine  Changsha P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan\u2010Fu","family":"Tang","sequence":"additional","affiliation":[{"name":"TCM and Ethnomedicine Innovation &amp; Development International Laboratory Innovative Materia Medica Research Institute School of Pharmacy Hunan University of Chinese Medicine  Changsha P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Yang","sequence":"additional","affiliation":[{"name":"TCM and Ethnomedicine Innovation &amp; Development International Laboratory Innovative Materia Medica Research Institute School of Pharmacy Hunan University of Chinese Medicine  Changsha P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin\u2010Guo","family":"Luo","sequence":"additional","affiliation":[{"name":"TCM and Ethnomedicine Innovation &amp; Development International Laboratory Innovative Materia Medica Research Institute School of Pharmacy Hunan University of Chinese Medicine  Changsha P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[{"name":"TCM and Ethnomedicine Innovation &amp; Development International Laboratory Innovative Materia Medica Research Institute School of Pharmacy Hunan University of Chinese Medicine  Changsha P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Yu","sequence":"additional","affiliation":[{"name":"TCM and Ethnomedicine Innovation &amp; Development International Laboratory Innovative Materia Medica Research Institute School of Pharmacy Hunan University of Chinese Medicine  Changsha P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,8]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/23802359.2021.1937359"},{"key":"e_1_2_10_3_1","volume-title":"Chinese Materia Medica (Zhonghua Bencao)","author":"Editorial Committee of Chinese Materia Medica","year":"1999"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules21080991"},{"key":"e_1_2_10_5_1","first-page":"722","article-title":"Isolation and Characterization of Phenylethanoid Glycosides From Clerodendron bungei","volume":"40","author":"Li Y. B.","year":"2005","journal-title":"Acta Pharmaceutica Sinica"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/10286020008039917"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.3254"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/hlca.200800392"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/np0703489"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2025.1597463"},{"key":"e_1_2_10_11_1","first-page":"124","article-title":"The Antineoplastic Activity Screening of Different Extracts From Clerodendrum bungei Steud and Their Effects on EMT\u2010Related Proteins in Nude Mice With Transplanted Tumor","volume":"36","author":"Yu N.","year":"2020","journal-title":"Pharmacology and Clinics of Chinese Materia Medica"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28247956"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11418\u2010021\u201001532\u2010y"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2019.104298"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tetlet.2015.01.081"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/10286020.2015.1096931"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/14786419.2020.1834548"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1080\/14786419.2021.1931189"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/14786419.2019.1586700"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jnatprod.8b00975"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9422(00)81521-6"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031\u20109422(98)00734\u20101"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.3389\/fvets.2021.813737"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40199\u2010021\u201000398\u20105"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcme.2017.04.001"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943\u2010022\u201001603\u2010y"}],"container-title":["Chemistry &amp; Biodiversity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbdv.202503074","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cbdv.202503074","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbdv.202503074","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T07:55:51Z","timestamp":1785484551000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cbdv.202503074"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":25,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1002\/cbdv.202503074"],"URL":"https:\/\/doi.org\/10.1002\/cbdv.202503074","archive":["Portico"],"relation":{},"ISSN":["1612-1872","1612-1880"],"issn-type":[{"value":"1612-1872","type":"print"},{"value":"1612-1880","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2025-09-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e03074"}}