{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T15:51:54Z","timestamp":1787500314967,"version":"build-2736575974"},"reference-count":64,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T00:00:00Z","timestamp":1776729600000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    A library of twelve new 1\u2010phenyl\u20101,2,3,4\u2010tetrahydroisoquinoline tethered 1\u2010phenyl\u20101\n                    <jats:italic>H<\/jats:italic>\n                    \u20101,2,3\u2010triazol\u20104\u2010yl\u2010methyl derivatives\n                    <jats:bold>7(a\u2010l)<\/jats:bold>\n                    were synthesized via copper\u2010catalyzed azide alkyne cycloaddition. The synthesized derivatives were characterized by\n                    <jats:sup>1<\/jats:sup>\n                    H\u2010NMR,\n                    <jats:sup>13<\/jats:sup>\n                    C\u2010NMR, and mass spectrometry techniques. All the derivatives were screened for in vitro antifungal activity against an opportunistic pathogen\n                    <jats:italic>Candida albicans<\/jats:italic>\n                    by broth microdilution method. The study revealed that compound\n                    <jats:bold>7i<\/jats:bold>\n                    exhibited the potent antifungal profile with minimum inhibitory concentration (MIC) of\n                    <jats:bold>6\u00a0\u00b5g\/mL<\/jats:bold>\n                    , minimum fungicidal concentration (MFC) of\n                    <jats:bold>32\u00a0\u00b5g\/mL,<\/jats:bold>\n                    and it demonstrated\n                    <jats:bold>82%<\/jats:bold>\n                    biofilm inhibition and\n                    <jats:bold>78%<\/jats:bold>\n                    filament inhibition. The results showed an improvement over the standard drug fluconazole which exhibited MIC of\n                    <jats:bold>8\u00a0\u00b5g\/mL<\/jats:bold>\n                    and MFC of\n                    <jats:bold>64\u00a0\u00b5g\/mL, 78%<\/jats:bold>\n                    biofilm inhibition, and\n                    <jats:bold>65%<\/jats:bold>\n                    of filament inhibition. Further the inhibition was confirmed by SEM analysis and qRT\u2010PCR was conducted against\n                    <jats:italic>HWP1<\/jats:italic>\n                    ,\n                    <jats:italic>EFG1<\/jats:italic>\n                    , and\n                    <jats:italic>ALS3<\/jats:italic>\n                    genes. In addition, an in silico molecular docking study was carried out to demonstrate the interactions between the synthesized compounds and target amino acids. ADMET analysis indicated all the compounds met the criteria of drug\u2010likeness and follow Lipinski's rule of five.\u00a0Further optimization of these derivatives could yield promising therapeutics for Candidal infections.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202503083","type":"journal-article","created":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T12:17:28Z","timestamp":1776773848000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Unveiling the Potential of Isoquinoline\u2010Tethered 1,2,3\u2010Triazoles as Promising Anti\u2010Biofilm Agents Against\n                    <i>Candida albicans<\/i>\n                    : Synthesis, Biological Evaluation, ADME, and Molecular Docking Studies"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-0649-9504","authenticated-orcid":false,"given":"Pooja 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