{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T00:52:20Z","timestamp":1787791940373,"version":"build-2784847793"},"reference-count":60,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T00:00:00Z","timestamp":1773273600000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Propolis is a polyphenol\u2010rich natural resin with well\u2010documented antioxidant activity; however, its practical application is restricted by poor aqueous solubility and limited stability. Herein, propolis\u2010based organic\u2013inorganic hybrid nanoflowers (Prp\u2010Nfs) were synthesized by integrating a propolis extract into a Cu\n                    <jats:sub>3<\/jats:sub>\n                    (PO\n                    <jats:sub>4<\/jats:sub>\n                    )\n                    <jats:sub>2<\/jats:sub>\n                    \u00b73H\n                    <jats:sub>2<\/jats:sub>\n                    O matrix under mild aqueous conditions (0.8\u00a0mM Cu\n                    <jats:sup>2<\/jats:sup>\n                    <jats:sup>+<\/jats:sup>\n                    , pH 7.4, 25\u00b0C, 72\u00a0h). SEM and laser diffraction analyses confirmed the formation of uniform spherical Prp\u2010Nfs with a relatively narrow size distribution. EDX, FTIR, and XRD analyses verified the formation of well\u2010integrated organic\u2010inorganic hybrid architecture arising from interactions between copper ions and propolis\u2010derived functional groups. Functionally, Prp\u2010Nfs exhibited markedly enhanced peroxidase\u2010like activity, reaching 2.76 EU mg\n                    <jats:sup>\u2212<\/jats:sup>\n                    <jats:sup>1<\/jats:sup>\n                    at pH 7.4 and 40\u00b0C, while retaining 58.1% of their initial activity after five reuse cycles. Despite a lower total phenolic content, Prp\u2010Nfs demonstrated superior DPPH radical scavenging activity (94.4%) together with a substantial ABTS antioxidant capacity (475.6\u00a0\u00b5mol Trolox g\n                    <jats:sup>\u2212<\/jats:sup>\n                    <jats:sup>1<\/jats:sup>\n                    ). Overall, these findings identify Prp\u2010Nfs as a propolis\u2010based hybrid nanozyme platform that combines peroxidase\u2010like catalytic activity with enhanced antioxidant functionality.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202503090","type":"journal-article","created":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T11:32:50Z","timestamp":1773315170000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Propolis\u2010Based Hybrid Nanoflowers as Multifunctional Nanozymes: Structural Integration of Polyphenols for Enhanced Catalytic and Antioxidant Activity"],"prefix":"10.1002","volume":"23","author":[{"given":"Cevahir","family":"Altinkaynak","sequence":"first","affiliation":[{"name":"Department of Plant and Animal Production, Avanos Vocational School Nevsehir Haci Bektas Veli University  Nevsehir T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatih","family":"Kirmizikar","sequence":"additional","affiliation":[{"name":"Department of Plant and Animal Production, Avanos Vocational School Nevsehir Haci Bektas Veli University  Nevsehir T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,12]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19061578"},{"issue":"2","key":"e_1_2_9_3_1","first-page":"122","article-title":"Propolisin Antikanser Aktivitesine Genel Bir Bak\u0131\u015f","volume":"5","author":"Dogan N.","year":"2022","journal-title":"JONAS"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27186120"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules191219610"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/206439"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.1990.tb126313.x"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/697390"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodres.2019.05.028"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11694\u2010019\u201000166\u20109"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13765-021-00608-3"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/life14111389"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph13050498"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/01635581.2016.1115096"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03175035"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/00218839.2019.1701777"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jab.2017.10.007"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.21889"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1051\/apido:19920306"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.897282"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-8741(02)00329-X"},{"issue":"1","key":"e_1_2_9_22_1","first-page":"57","article-title":"Immune's\u2010Boosting Agent: Immunomodulation Potentials of Propolis","volume":"26","author":"Al\u2010Hariri M.","year":"2019","journal-title":"JFCM"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2012.02.097"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.14740"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/1972714"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0308\u20108146(03)00216\u20104"},{"key":"e_1_2_9_27_1","doi-asserted-by":"crossref","unstructured":"T. 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