{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T17:20:42Z","timestamp":1787505642079,"version":"build-2736575974"},"reference-count":40,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T00:00:00Z","timestamp":1773446400000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    UC is a globally escalating intestinal disorder with limited safe and effective interventions. This study investigated the synergistic therapeutic effects and mechanisms of\n                    <jats:italic>Lactobacillus johnsonii<\/jats:italic>\n                    46 (\n                    <jats:italic>L. johnsonii<\/jats:italic>\n                    46) (a feruloyl esterase\u2010producing strain) and rice bran (LJRB) on DSS\u2010induced UC in C57BL\/6J mice. The animal groups were divided into control group (CON), DSS group (MOD), sulfasalazine group (SUL), rice bran group (RBN),\n                    <jats:italic>L. johnsonii<\/jats:italic>\n                    46 group (LAJ), and LJRB treatment group (RBL). The organ index, disease index, and biochemical indicators of mice were measured, the histopathology of the colon was analyzed. The expression of inflammatory factor, tight junction protein and TLRs\/TRAF6\/NF\u2010\u03baB signaling pathway genes were detected by Real\u2010Time Quantitative Polymerase Chain Reaction (RT\u2010qPCR). LJRB supplementation exerted superior protective effects compared to single rice bran (RBN) or\n                    <jats:italic>L. johnsonii<\/jats:italic>\n                    46 (LAJ) intervention: it significantly alleviated DSS\u2010induced weight loss (RBL group: 1.46 \u00b1 0.21\u00a0g vs. MOD group: \u223c3\u00a0g,\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.05), restored colon length, and reduced the disease activity index (DAI) by \u223c50%. Biochemical and molecular analyses showed LJRB remarkably suppressed serum pro\u2010inflammatory cytokines (IL\u20101\u03b2, TNF\u2010\u03b1, IL\u20106; 40%\u201360% reduction vs. MOD group) while elevating anti\u2010inflammatory IL\u201010 (\u223c35% increase), enhanced colonic antioxidant capacity (reduced MDA by \u223c30% and increased SOD, GSH, GSH\u2010Px by 25%\u201340%), and enriched cecal short\u2010chain fatty acids (SCFAs) with acetic acid (0.99\u00a0\u00b5mol\/g), propionic acid (0.31\u00a0\u00b5mol\/g), and butyric acid (0.21\u00a0\u00b5mol\/g) significantly higher than the MOD group. Mechanistically, LJRB synergistically inhibited the TLRs\/TRAF6\/NF\u2010\u03baB signaling pathway, as indicated by downregulated mRNA expression of TLR4, MyD88, IKK\u03b2, and NF\u2010\u03baB p65 (30%\u201350% reduction vs. MOD group) and decreased phosphorylation of IKK\u03b2, I\u03baB\u03b1, and NF\u2010\u03baB p65 proteins. Histopathological observations confirmed LJRB preserved colon tissue integrity, reduced goblet cell loss, and alleviated mucosal erosion and edema. Collectively, these findings demonstrate LJRB alleviates UC through multi\u2010targeted mechanisms (anti\u2010inflammation, antioxidation, SCFA production promotion, and nuclear factor kappa\u2010B (NF\u2010\u03baB) pathway inhibition), highlighting its potential as a novel natural dietary supplement for UC prevention and management.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202503104","type":"journal-article","created":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T11:01:48Z","timestamp":1773486108000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Synergistic Effect of Rice Bran and Lactobacillus Ferulate Esterase on Dextran Sodium Sulfate (DSS)\u2010Induced Ulcerative Colitis (UC) in Mice"],"prefix":"10.1002","volume":"23","author":[{"given":"Yingjian","family":"Lu","sequence":"first","affiliation":[{"name":"College of Food Science and Engineering Nanjing University of Finance and Economics  Nanjing P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Le","family":"Li","sequence":"additional","affiliation":[{"name":"College of Food Science and Engineering Nanjing University of Finance and Economics  Nanjing P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuolun","family":"Xin","sequence":"additional","affiliation":[{"name":"College of Food Science and Engineering Nanjing University of Finance and Economics  Nanjing P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7258-295X","authenticated-orcid":false,"given":"Xiangfei","family":"Li","sequence":"additional","affiliation":[{"name":"College of Food Science and Engineering Nanjing University of Finance and Economics  Nanjing P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,14]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2015.150"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(16)32126\u20102"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodres.2020.109409"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1039\/D5FO90056E"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265\u2010025\u201002227\u20104"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.202400295"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13020\u2010023\u201000735\u20107"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/life13040948"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28104189"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1FO00317H"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lwt.2025.118415"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biortech.2003.08.010"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0008\u20106215(00)00096\u20103"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biortech.2024.130387"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2017.00941"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.2c02066"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.9b06477"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fbp.2023.05.004"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9FO02772F"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.17179\/excli2021\u20103762"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2019.103470"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1039\/D5FO90056E"},{"key":"e_1_2_8_24_1","volume-title":"Bancroft's Theory and Practice of Histological Techniques","author":"Suvarna K.","year":"2018"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.3390\/foods14111865"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7FO90032E"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1179721"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2024.136186"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.28.10.1221"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2021.103293"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9FO00014C"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/8785497"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12079\u2010022\u201000695\u2010x"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2024.113671"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOG.0000000000001066"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1196065"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00284\u2010022\u201002825\u20105"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12950\u2010021\u201000298\u20100"},{"key":"e_1_2_8_39_1","first-page":"618","article-title":"NF\u2010\u03baB Signaling in Inflammation and Cancer","volume":"2","author":"Zhang T.","year":"2021","journal-title":"Medicine Communications"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbf.3927"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcdf.2015.06.002"}],"container-title":["Chemistry &amp; 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