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The targeted quinoline hydrazone derivatives (\n                    <jats:bold>6a<\/jats:bold>\n                    \u2013\n                    <jats:bold>j<\/jats:bold>\n                    ) were synthesized via a two\u2010step process, beginning with the preparation of the essential quinoline hydrazide intermediate\n                    <jats:bold>5<\/jats:bold>\n                    , followed by its condensation with substituted aromatic aldehydes. Advanced spectroscopic techniques, including\n                    <jats:sup>1<\/jats:sup>\n                    H NMR,\n                    <jats:sup>13<\/jats:sup>\n                    C NMR, and HRMS, confirmed their structures. Comprehensive computational studies, comprising DFT, molecular docking, and molecular dynamics, were performed to establish structure\u2013activity relationships and substantiate the biological results. The derivatives exhibited notable dual activity; specifically,\n                    <jats:bold>6a<\/jats:bold>\n                    (\n                    <jats:italic>p<\/jats:italic>\n                    \u2010OH) displayed the highest antibacterial efficacy against\n                    <jats:italic>Escherichia coli<\/jats:italic>\n                    (MIC\u00a0=\u00a031.25\u00a0\u00b5g\/mL). Compound\n                    <jats:bold>6d<\/jats:bold>\n                    (\n                    <jats:italic>p<\/jats:italic>\n                    \u2010Cl) demonstrated the fastest onset of in vivo anti\u2010inflammatory activity, exceeding diclofenac. Most compounds demonstrated comparable or slightly reduced in vitro anti\u2010inflammatory activity (81.25%\u201394.59% hemolysis inhibition). Molecular dynamics simulations confirmed the stability and robust binding interactions at the active sites of COX\u20102 and bacterial DNA gyrase B. ADMET predictions indicated favorable bioavailability and drug likeness. This study underscores the potential of the nonacidic quinoline hydrazone scaffold as a versatile platform for the development of multi\u2010target therapeutics and offers valuable SAR insights to guide the design of safer, more efficacious agents.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202503108","type":"journal-article","created":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T08:50:29Z","timestamp":1768726229000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Design, Synthesis, and Integrated Computational Evaluation of Novel Quinoline Hydrazones as Dual\u2010Action Anti\u2010Inflammatory and Antibacterial Agents"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2864-9827","authenticated-orcid":false,"given":"Bachir","family":"Douara","sequence":"first","affiliation":[{"name":"Laboratoire de Phytochimie et de Pharmacologie, D\u00e9partement de Chimie, Facult\u00e9 des Sciences Exactes et Informatique Universit\u00e9 de Jijel  Jijel Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-6894-0551","authenticated-orcid":false,"given":"Katia","family":"Mohand Saidi","sequence":"additional","affiliation":[{"name":"Laboratoire de Phytochimie et de Pharmacologie, D\u00e9partement de Chimie, Facult\u00e9 des Sciences Exactes et Informatique Universit\u00e9 de Jijel  Jijel Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6093-6965","authenticated-orcid":false,"given":"Lotfi","family":"Belkhiri","sequence":"additional","affiliation":[{"name":"Centre de Recherche en Sciences Pharmaceutiques CRSP, ZAM Ali Mendjeli  Constantine Algeria"},{"name":"Laboratoire de Physique Math\u00e9matique et Subatomique LPMS, D\u00e9partement de Chimie Universit\u00e9 des Fr\u00e8res Mentouri  Constantine Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6434-664X","authenticated-orcid":false,"given":"Nassima","family":"Boutaoui","sequence":"additional","affiliation":[{"name":"Laboratoire de Phytochimie et de Pharmacologie, D\u00e9partement de Chimie, Facult\u00e9 des Sciences Exactes et Informatique Universit\u00e9 de Jijel  Jijel Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5504-9827","authenticated-orcid":false,"given":"Mohamed Zakaria","family":"Stiti","sequence":"additional","affiliation":[{"name":"Laboratoire de Phytochimie et de Pharmacologie, D\u00e9partement de Chimie, Facult\u00e9 des Sciences Exactes et Informatique Universit\u00e9 de Jijel  Jijel Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7343-0242","authenticated-orcid":false,"given":"Smail","family":"Khelili","sequence":"additional","affiliation":[{"name":"Laboratoire de Phytochimie et de Pharmacologie, D\u00e9partement de Chimie, Facult\u00e9 des Sciences Exactes et Informatique Universit\u00e9 de Jijel  Jijel Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1795-1684","authenticated-orcid":false,"given":"Ramzi","family":"Maadadi","sequence":"additional","affiliation":[{"name":"Centre de Recherche en Sciences Pharmaceutiques CRSP, ZAM Ali Mendjeli  Constantine Algeria"},{"name":"Centre de Recherche Scientifique et Technique en Analyses Physico\u2010Chimiques (CRAPC)  Tipaza Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7138-787X","authenticated-orcid":false,"given":"Abdelmadjid","family":"Guendouzi","sequence":"additional","affiliation":[{"name":"Laboratoire de Chimie, Synth\u00e8se, Propri\u00e9t\u00e9s et Applications LCSPA, D\u00e9partement de Chimie, Facult\u00e9 des Sciences Universit\u00e9 de Saida  Saida Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9476-0489","authenticated-orcid":false,"given":"Abdelkrim","family":"Guendouzi","sequence":"additional","affiliation":[{"name":"URCHEMS, D\u00e9partement de Chimie Universit\u00e9 Constantine 1 Fr\u00e8res Mentouri  Constantine Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,18]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13098\u2010016\u20100159\u2010z"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2014.01.020"},{"key":"e_1_2_9_4_1","first-page":"S1","article-title":"Infection and Inflammatory Mechanisms","volume":"84","author":"Van Dyke T. 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