{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T12:46:55Z","timestamp":1775998015017,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T00:00:00Z","timestamp":1773273600000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Seventeen compounds, including seven undescribed compounds named Zingiberenes A\u2013G (1\u20137), were isolated from the traditional medicinal plant\n                    <jats:italic>Zingiber montanum<\/jats:italic>\n                    . Their planar structures and absolute configurations were established by comprehensive spectroscopic analysis and ECD calculations. Evaluation of anti\u2010inflammatory activity in LPS\/IFN\u2010\n                    <jats:italic>\u03b3<\/jats:italic>\n                    \u2010stimulated RAW264.7 macrophages showed that compounds\n                    <jats:bold>1<\/jats:bold>\n                    and\n                    <jats:bold>4<\/jats:bold>\n                    significantly inhibited NO production (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.01), with\n                    <jats:bold>4<\/jats:bold>\n                    exhibiting the strongest effect. At 10 \u00b5M, both compounds also suppressed the secretion of pro\u2010inflammatory cytokines TNF\u2010\n                    <jats:italic>\u03b1<\/jats:italic>\n                    and IL\u20106 by 30%\u201350% (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.01). Network pharmacology analysis predicted multi\u2010target anti\u2010inflammatory mechanisms involving IL\u20106, GAPDH, and PTGS2. Molecular docking further supported these findings, demonstrating that compound\n                    <jats:bold>4<\/jats:bold>\n                    forms a stable complex with IL\u20106, which aligns with the experimental NO and cytokine data. This study offers valuable insights for future research on the anti\u2010inflammatory mechanisms of phenylbutene derivatives.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202503174","type":"journal-article","created":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T11:43:04Z","timestamp":1773315784000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Phenylbutene and Phenylpropanoid Constituents From\n                    <i>Zingiber montanum<\/i>\n                    and Their Anti\u2010Inflammatory Activity in Macrophages"],"prefix":"10.1002","volume":"23","author":[{"given":"Zhi\u2010Hang","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Medicinal Chemistry and Natural Medicine Chemistry, College of Pharmacy Harbin Medical University  Harbin PR 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