{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T07:00:35Z","timestamp":1775890835005,"version":"3.50.1"},"reference-count":46,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T00:00:00Z","timestamp":1770940800000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The integration of sustainable synthesis with biological relevance is a key objective in contemporary medicinal chemistry. Herein, we report a catalyst\u2010free, one\u2010pot multicomponent protocol for the rapid synthesis of spirooxindole\u2010based pseudo\u2010natural products under mild and environmentally benign conditions. The reaction proceeds efficiently in methanol at room temperature, affording high yields (80%\u201390%) within 30\u00a0min without the need for external catalysts or chromatographic purification, highlighting its operational simplicity and scalability. Mechanistic studies suggest the in situ formation of a stable azomethine ylide, which undergoes a highly diastereoselective [3+2] cycloaddition and enables broad substrate tolerance across electron\u2010deficient isatins and substituted maleimides. Biological evaluation using a methyl methanesulfonate\u2010induced oxidative stress model in human lymphocytes revealed distinct structure\u2013activity relationships. Compounds\n                    <jats:bold>4c<\/jats:bold>\n                    and\n                    <jats:bold>4i<\/jats:bold>\n                    significantly reduced intracellular reactive oxygen species and restored cell viability close to control levels, identifying them as promising antioxidative leads. Overall, this study demonstrates a sustainable approach to structurally diverse spirooxindole scaffolds with potential relevance to redox\u2010associated pathologies.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202503182","type":"journal-article","created":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T11:28:04Z","timestamp":1770982084000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Catalyst\u2010Free Green Synthesis of Spirooxindole Pseudo\u2010Natural Products With Anti\u2010ROS and Cytoprotective Effects"],"prefix":"10.1002","volume":"23","author":[{"family":"Farhanaz","sequence":"first","affiliation":[{"name":"Department of Chemistry Aligarh Muslim University  Aligarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohd Kamil","family":"Hussain","sequence":"additional","affiliation":[{"name":"Department of Chemistry Govt. Raza P.G. 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