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Among the isolated compounds, trachyloban\u201015\u03b1\u201018\u2010diol exhibited the most significant bioactivity, with metal chelating and free radical scavenging activities of 3.79 \u00b1 0.67 and 3.88 \u00b1 1.03\u00a0\u00b5g\/mL, respectively. These quantitative results underscore the potential of\n                    <jats:italic>Croton<\/jats:italic>\n                    species as a source of potent antioxidants. The reducing power of crotozambefuran A was 43.30 \u00b1 0.01\u00a0\u00b5g\/mL. Trachinodiol and sitoindoside I demonstrated the lowest MIC value of 64\u00a0\u00b5g\/mL against\n                    <jats:italic>E. coli<\/jats:italic>\n                    . The 3\u2010O\u2010acetylaleuritolic acid was the most effective against\n                    <jats:italic>B. cereus<\/jats:italic>\n                    (&lt;1). The binding affinity and constant of Sitoindoside I for BSA are \u20107.90\u00a0kcal\/mol and 1.59\u00a0\u00b5M, respectively. ADMET prediction suggested favorable pharmacokinetic properties for trachyloban\u201015\u03b1\u201018\u2010diol, including high gastrointestinal absorption and potential blood\u2010brain barrier permeability. Trachyloban\u201015a\u201018\u2010diol &gt;\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2010sitosterol palmitate &gt; cytoindosit I &gt; 4\u2010hydroxy\u20103\u2010methoxybenzaldehyde is the sequence from the most to the least stable molecules. Trachyloban\u201015\u03b1\u201018\u2010diol is nucleophilic and has the lowest electrophilicity index value (0.043\u00a0eV). The in silico studies, including molecular docking with BSA and ADMET profiling, were conducted to evaluate the pharmacokinetic behavior and transport potential of the isolated compounds rather than their direct enzymatic inhibition mechanisms. These findings indicate that trachyloban\u201015\u03b1\u201018\u2010diol may warrant further investigation as a bioactive lead compound.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202503192","type":"journal-article","created":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T07:45:27Z","timestamp":1783496727000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Exploratory Studies on Diterpenoids and Other Constituents From the Root Bark of\n                    <i>Croton oligandrum<\/i>\n                    Pierre Ex Hutch (Euphorbiaceae) via Biological Activities and In Silico Evaluations"],"prefix":"10.1002","volume":"23","author":[{"given":"Destaing F.","family":"Abega","sequence":"first","affiliation":[{"name":"Department of Organic Chemistry Faculty of Science University of Yaound\u00e9 I  Yaound\u00e9 Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Semiha","family":"Yenigun","sequence":"additional","affiliation":[{"name":"Department of Chemistry Faculty of Science Ondokuz May\u0131s University  Samsun Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8946-647X","authenticated-orcid":false,"given":"Ibrahim","family":"Demirtas","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry Faculty of Pharmacy Ondokuz May\u0131s University  Samsun Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick Y.","family":"Ango","sequence":"additional","affiliation":[{"name":"Department of Pharmacotoxicology Faculty of Medicine and Biomedical Sciences University of Yaound\u00e9 I.  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