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Mutations in IDH lead to abnormal epigenetic regulation in AML cells and block differentiation. Inhibitors of mutated IDH1 and IDH2, vorasidenib, ivosidenib, olutasidenib, and enasidenib, respectively, were recently approved by the FDA for relapsed\/refractory AML. In this review, we mainly focus on IDH inhibitors in leukemia therapy, including the discovery, structure optimization, activity of IDH inhibitors, and applications, which provided the reference for the discovery of new anticancer agents.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202503194","type":"journal-article","created":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T20:20:44Z","timestamp":1770668444000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Isocitrate Dehydrogenase Inhibitors in Acute Myeloid Leukemia"],"prefix":"10.1002","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7998-1272","authenticated-orcid":false,"given":"Qiuzi","family":"Dai","sequence":"first","affiliation":[{"name":"The Hunan Provincial University Key Laboratory of the Fundamental and Clinical Research on Functional Nucleic Acid Changsha Medical University  Changsha China"},{"name":"The First Affiliated 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University  Changsha China"},{"name":"The First Affiliated Hospital of Changsha Medical University  Changsha China"},{"name":"Hunan Provincial Key Laboratory of the Traditional Chinese Medicine Agricultural Biogenomics Changsha Medical University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaqian","family":"Li","sequence":"additional","affiliation":[{"name":"The Hunan Provincial University Key Laboratory of the Fundamental and Clinical Research on Functional Nucleic Acid Changsha Medical University  Changsha China"},{"name":"The First Affiliated Hospital of Changsha Medical University  Changsha China"},{"name":"Hunan Provincial Key Laboratory of the Traditional Chinese Medicine Agricultural Biogenomics Changsha Medical University  Changsha 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