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Compounds\n                    <jats:bold>1a\/1b<\/jats:bold>\n                    \u2013\n                    <jats:bold>3a\/3b<\/jats:bold>\n                    were further separated by chiral\u2010phase high\u2010performance liquid chromatography. The structures were elucidated by comprehensive spectroscopic analysis, high\u2010resolution electrospray ionization mass spectrometry, time\u2010dependent density functional theory\/electronic circular dichroism calculation, and X\u2010ray diffraction analysis. In bioassays, compounds\n                    <jats:bold>1<\/jats:bold>\n                    \u2013\n                    <jats:bold>5<\/jats:bold>\n                    exhibited moderate nitric oxide inhibition from 28.2% to 51.9% on RAW264.7 inflammatory cells at 20 \u00b5M without notable cytotoxicity.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202503208","type":"journal-article","created":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T11:56:43Z","timestamp":1767873403000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Placidenes G\u2013J, Bioactive\n                    <i>\u03b3<\/i>\n                    \u2010Pyrone Derivatives From the Marine Mollusk\n                    <i>Placida dendritica<\/i>"],"prefix":"10.1002","volume":"23","author":[{"given":"Hao","family":"Wang","sequence":"first","affiliation":[{"name":"College of Pharmacy Shandong University of Traditional Chinese Medicine  Jinan China"},{"name":"Shandong Laboratory of Yantai Drug Discovery Bohai Rim Advanced Research Institute for Drug Discovery  Yantai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen\u2010Xuan","family":"Li","sequence":"additional","affiliation":[{"name":"Shandong Laboratory of Yantai Drug Discovery Bohai Rim Advanced Research Institute for Drug Discovery  Yantai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Ru","sequence":"additional","affiliation":[{"name":"College of Pharmacy Shandong University of Traditional Chinese Medicine  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Gao","sequence":"additional","affiliation":[{"name":"Shandong Laboratory of Yantai Drug Discovery Bohai Rim Advanced Research Institute for Drug Discovery  Yantai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7919-9726","authenticated-orcid":false,"given":"Xu\u2010Wen","family":"Li","sequence":"additional","affiliation":[{"name":"College of Pharmacy Shandong University of Traditional Chinese Medicine  Jinan China"},{"name":"Shandong Laboratory of Yantai Drug Discovery Bohai Rim Advanced Research Institute for Drug Discovery  Yantai China"},{"name":"State Key Laboratory of Chemical Biology Shanghai Institute of Materia Medica, Chinese Academy of Sciences  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,8]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.2174\/1385272824666200217101400"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s42995\u2010023\u201000179\u2010w"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0040\u20104020(00)00751\u20101"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/14786419.2019.1569010"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/ol0477428"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/np50104a017"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010020\u201016376\u20105"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/md17060322"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.5c01274"},{"key":"e_1_2_10_11_1","first-page":"570","article-title":"Salinipyrones and Pacificanones, Mixed\u2010Precursor Polyketides From the Marine Actinomycete Salinispora pacifica","volume":"71","author":"Dong\u2010Chan O.","year":"2018","journal-title":"Journal of Natural Products"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/14786419.2016.1164702"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tetlet.2016.03.084"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202003643"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/np0300176"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0040\u20104039(00)78884\u20108"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1107\/S2053273314026370"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1107\/S0021889808042726"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1107\/S2053229614024218"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/chir.22138"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2QO01265K"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.4c00950"}],"container-title":["Chemistry &amp; 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