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It is used to treat inflammation, paralysis, and brain\u2010related problems. The literature revealed that\n                    <jats:italic>E. royleana<\/jats:italic>\n                    was not well explored for phytochemical diversity and health benefits. Therefore, the current study was focused on investigating solvent\u2010dependent chemical diversity and bioactive properties across stems, leaves, and reproductive tissue (flowers and seeds). Ethanol, 50% ethanol, and water extracts were prepared, in which the water extract of leaves showed the highest extraction efficiency (16.97%). Total phenolic content was found higher in 50% ethanol extract (112.65 \u00b1 3.27\u00a0mg GAE\/g), while flavonoid content was found higher in ethanol extract (217.31 \u00b1 13.55\u00a0mg RE\/g) of reproductive parts. Further, UPLC\u2010PDA\u2010based targeted polyphenol profiling showed gallic acid (23.658 \u00b1 mg\/g) as the most abundant polyphenol among different parts. UHPLC\u2010QTOF\u2010IMS\u2010based non\u2010targeted metabolite profiling revealed 74 metabolites (terpenoids, flavonoid glycosides, and phenylpropanoids). Multivariate statistical analysis of identified metabolites further suggested clear organ\u2010 and solvent\u2010specific variations. Moreover, antioxidant and tyrosinase inhibition activities were performed, and the highest activity was found in the ethanol extract of reproductive tissues. The current study provides new insights into the chemical diversity of\n                    <jats:italic>E. royleana<\/jats:italic>\n                    , highlighting its ecological significance and chemotaxonomic value within Euphorbiaceae.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202503217","type":"journal-article","created":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T04:26:50Z","timestamp":1773030410000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Metabolome Analysis and Functional Activities of\n                    <i>Euphorbia royleana<\/i>\n                    Boiss. Indicating Potential Health Benefits"],"prefix":"10.1002","volume":"23","author":[{"given":"Pallavi","family":"Kumari","sequence":"first","affiliation":[{"name":"Department of Chemistry, School of Basic &amp; Applied Sciences Career Point University  Hamirpur Himachal Pradesh India"},{"name":"Chemical Technology Division CSIR\u2010Institute of Himalayan Bioresource Technology  Palampur Himachal Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rishabh","family":"Kaundal","sequence":"additional","affiliation":[{"name":"Chemical Technology Division CSIR\u2010Institute of Himalayan Bioresource Technology  Palampur Himachal Pradesh India"},{"name":"Academy of Scientific and Innovative Research  Ghaziabad Uttar Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajender","family":"Kumar","sequence":"additional","affiliation":[{"name":"Chemical Technology Division CSIR\u2010Institute of Himalayan Bioresource Technology  Palampur Himachal Pradesh India"},{"name":"Academy of Scientific and Innovative Research  Ghaziabad Uttar Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yogesh Kumar","family":"Walia","sequence":"additional","affiliation":[{"name":"Department of Chemistry, School of Basic &amp; Applied Sciences Career Point University  Hamirpur Himachal Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4123-0235","authenticated-orcid":false,"given":"Dinesh","family":"Kumar","sequence":"additional","affiliation":[{"name":"Chemical Technology Division CSIR\u2010Institute of Himalayan Bioresource Technology  Palampur Himachal Pradesh India"},{"name":"Academy of Scientific and Innovative Research  Ghaziabad Uttar Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,2]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.4314\/ajtcam.v8i1.60483"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2008.03.008"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1590\/s0100\u2010879x2004000300015"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biotechadv.2015.08.001"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd4510"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25174019"},{"key":"e_1_2_9_8_1","first-page":"652","article-title":"Why Do Euphorbiaceae Tick as Medicinal Plants? 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