{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T08:01:50Z","timestamp":1785484910760,"version":"3.56.0"},"reference-count":16,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T00:00:00Z","timestamp":1763078400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T00:00:00Z","timestamp":1763078400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2026,1]]},"abstract":"ABSTRACT<\/jats:title>\n \n A new scalarane\u2010type sesterterpene (\n 1<\/jats:bold>\n ), along with four known related compounds (\n 2<\/jats:bold>\n \u2013\n 5<\/jats:bold>\n ), was isolated from the nudibranch mollusk\n Glossodoris hikuerensis<\/jats:italic>\n . Compound\n 6<\/jats:bold>\n was also obtained from\n 4<\/jats:bold>\n by chemical conversion. Their structures were established by extensive spectroscopic analysis, chemical conversion, and by the comparison of their spectroscopic data with those reported in the literature. In bioassay, compound\n 1<\/jats:bold>\n inhibited the proliferation of human leukemia U937 cells with a half\u2010maximal inhibitory concentration (IC\n 50<\/jats:sub>\n ) value of 7.1 \u00b5M. Compounds\n 2<\/jats:bold>\n ,\n 3<\/jats:bold>\n , and\n 6<\/jats:bold>\n exhibited inhibitory activities against a variety of human cancer cell lines, including U937, K562, A549, HCC827, and gefitinib\u2010resistant HCC827 cells, with IC\n 50<\/jats:sub>\n values 0.7\u221210.1 \u00b5M. Furthermore, compound\n 6<\/jats:bold>\n significantly induced apoptosis, reduced mitochondrial membrane potential, and suppressed cellular invasion and migration by inhibiting EGFR\/PI3K signaling pathway.\n <\/jats:p>","DOI":"10.1002\/cbdv.202503257","type":"journal-article","created":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T18:33:04Z","timestamp":1763145184000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Discovery of Scalarane Sesterterpenoids From the Mollusk\n Glossodoris hikuerensis<\/i>\n Exhibiting Anticancer Effects Against Drug\u2010resistant Lung Cancer Cells"],"prefix":"10.1002","volume":"23","author":[{"given":"Xiao","family":"Xiao","sequence":"first","affiliation":[{"name":"School of Medicine Shanghai University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li\u2010Ting","family":"Zhang","sequence":"additional","affiliation":[{"name":"Shandong 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