{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T13:16:09Z","timestamp":1787318169041,"version":"build-2736575974"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T00:00:00Z","timestamp":1767830400000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Recent investigations have identified prenylated isoflavonoids as major constituents of\n                    <jats:italic>Erythrina addisoniae<\/jats:italic>\n                    , yet their anti\u2010neuroinflammatory potential remains unexplored. Through bioassay\u2010guided isolation, two new prenylated isoflavonoids (\n                    <jats:bold>1<\/jats:bold>\n                    and\n                    <jats:bold>2<\/jats:bold>\n                    ), along with nine known compounds (\n                    <jats:bold>3<\/jats:bold>\n                    \u2013\n                    <jats:bold>11<\/jats:bold>\n                    ), were characterized using spectroscopic methods. All isolates were tested for inhibitory effects on nitric oxide (NO) production in BV\u20102 microglial cells. Compounds\n                    <jats:bold>1<\/jats:bold>\n                    ,\n                    <jats:bold>6<\/jats:bold>\n                    ,\n                    <jats:bold>7<\/jats:bold>\n                    , and\n                    <jats:bold>10<\/jats:bold>\n                    significantly reduced NO levels, with compounds\n                    <jats:bold>1<\/jats:bold>\n                    and\n                    <jats:bold>10<\/jats:bold>\n                    showing the strongest activity (IC\n                    <jats:sub>50<\/jats:sub>\n                    values of 3.57\u00a0\u00b1\u00a01.22 and 0.69\u00a0\u00b1\u00a00.18\u00a0\u00b5M, respectively). Western blot analysis confirmed the downregulation of inducible NO synthase protein, and molecular docking analysis revealed that compound\n                    <jats:bold>10<\/jats:bold>\n                    interacts with nuclear factor kappa\u2010light\u2010chain\u2010enhancer of activated B cells. These results highlight prenylated isoflavonoids from\n                    <jats:italic>E. addisoniae<\/jats:italic>\n                    as potential anti\u2010neuroinflammatory agents.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202503261","type":"journal-article","created":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T11:09:36Z","timestamp":1767870576000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["New Prenylated Isoflavonoids From\n                    <i>Erythrina addisoniae<\/i>\n                    With Anti\u2010Neuroinflammatory Activity via Nuclear Factor Kappa\u2010Light\u2010Chain\u2010Enhancer of Activated B Cells Pathway Suppression"],"prefix":"10.1002","volume":"23","author":[{"given":"Jin\u2010Pyo","family":"An","sequence":"first","affiliation":[{"name":"Research Institute of Pharmaceutical Sciences, College of Pharmacy Seoul National University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gi Hyeon","family":"Seong","sequence":"additional","affiliation":[{"name":"Research Institute of Pharmaceutical Sciences, College of Pharmacy Seoul National University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YunHui","family":"Che","sequence":"additional","affiliation":[{"name":"Research Institute of Pharmaceutical Sciences, College of Pharmacy Seoul National University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge\u2010Eduardo","family":"Ponce\u2010Zea","sequence":"additional","affiliation":[{"name":"Research Institute of Pharmaceutical Sciences, College of Pharmacy Seoul National University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Van\u2010Hieu","family":"Mai","sequence":"additional","affiliation":[{"name":"Research Institute of Pharmaceutical Sciences, College of Pharmacy Seoul National University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derek Tantoh","family":"Ndinteh","sequence":"additional","affiliation":[{"name":"Department of Chemical Sciences, Center for Natural Product Research (CNPR) University of Johannesburg  Johannesburg South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph Tanyi","family":"Mbafor","sequence":"additional","affiliation":[{"name":"Department of Organic Chemistry, Laboratory No. 3 of Organic Chemistry, Faculty of Science University of Yaound\u00e9 I  Yaound\u00e9 Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0761-3064","authenticated-orcid":false,"given":"Won Keun","family":"Oh","sequence":"additional","affiliation":[{"name":"Research Institute of Pharmaceutical Sciences, College of Pharmacy Seoul National University  Seoul Republic of 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