{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T16:04:11Z","timestamp":1785341051818,"version":"3.55.0"},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T00:00:00Z","timestamp":1775692800000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Hypertension associated with elevated ACE activity highlights the need for exploring marine\u2010derived bioactive compounds, particularly from brown seaweeds, as potential natural ACE inhibitors. A chemical study of specialized bioactive compounds from the brown seaweed\n                    <jats:italic>Sargassum tenerrimum<\/jats:italic>\n                    (family Sargassaceae) led to the isolation of an unprecedented glycoside, Tenerriside A, which was characterized as 8\u2010((\u221214,16\u2010dihydroxy\u201017\u2010(hydroxymethyl)\u20104\u2010((\u221220,21,22\u2010trihydroxy\u201019\u2010(hydroxymethyl)tetrahydro\u20102H\u2010pyranyl)oxy)tetrahydro\u20102H\u2010pyranyl)oxy)\u201013\u2010(hydroxymethyl)pent\u201011\u2010enyl heptanoate. Tenerriside A exhibited ACE inhibitory activity with an IC\n                    <jats:sub>50<\/jats:sub>\n                    of 2.61\u00a0\u00b5M and exhibited strong antioxidant activity against free radicals (IC\n                    <jats:sub>50<\/jats:sub>\n                    \u223c21.67\u00a0\u00b5M), further supporting its potential anti\u2010hypertensive efficacy. Electronic parameters, such as a topological polar surface area of 225.06 \u00c5\n                    <jats:sup>2<\/jats:sup>\n                    , molecular polarizability of 54.47, may enhance recognition at the active enzyme site and lead to the effective inhibition of ACE and improved permeability across intermembrane barriers. Moreover, the low binding energy (\u221211.95\u00a0kcal\/mol) and docking score (\u221214.15\u00a0kcal\/mol) of Tenerriside A with the key amino acid residues in the ACE active site further support its anti\u2010hypertensive bioactivity.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202503270","type":"journal-article","created":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T06:08:56Z","timestamp":1775801336000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Tenerriside A, a Glycoside Variant From\n                    <i>Sargassum tenerrimum<\/i>\n                    , Exhibits Potent Angiotensin\u2010Converting Enzyme (ACE) Inhibitory Activity"],"prefix":"10.1002","volume":"23","author":[{"given":"Chaithanya","family":"Bose","sequence":"first","affiliation":[{"name":"Marine Biotechnology Fish Nutrition and Health Division ICAR\u2010Central Marine Fisheries Research Institute Cochin Kerala India"},{"name":"Department of Applied Chemistry Cochin University of Science and Technology  Cochin Kerala India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7105-8942","authenticated-orcid":false,"given":"Kajal","family":"Chakraborty","sequence":"additional","affiliation":[{"name":"Marine Biotechnology Fish Nutrition and Health Division ICAR\u2010Central Marine Fisheries Research Institute Cochin Kerala India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silpa Kunnappilly","family":"Paulose","sequence":"additional","affiliation":[{"name":"Marine Biotechnology Fish Nutrition and Health Division ICAR\u2010Central Marine Fisheries Research Institute Cochin Kerala India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,9]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40199\u2010019\u201000319\u20107"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/md19090484"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.9734\/JOCAMR\/2017\/29435"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10719\u2010025\u201010180\u20103"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2020.06.281"},{"key":"e_1_2_9_7_1","first-page":"65","article-title":"Phytochemical and Antibacterial Screening of Crude Extract of Sargassum tenerrimum J. 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