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EO from autumn leaves (EO\u2010A) contained 80 metabolites (93.8%), with limonene (28.5%), (+)\u2010\u03b2\u2010pinene (15.0%), cyclocolorenone (12.8%), 6,9\u2010guaiadiene (3.1%), and 4\u2010carvomenthenol (3.1%) as major constituents. EO from winter leaves (EO\u2010W) comprised 102 compounds (88.0%), dominated by \u03b2\u2010bisabolene (16.4%), \u03b2\u2010gurjunene (6.4%), \u03b2\u2010caryophyllene (4.7%), cyclocolorenone (3.9%), and dihydrocarveol (3.3%). The antimicrobial activity of both EOs was evaluated in vitro using the disk diffusion method against gram\u2010positive and gram\u2010negative bacteria, as well as selected yeast strains. MIC values ranged from 0.016 to 0.270 \u00b5g\u00b7mL\n                    <jats:sup>\u2212<\/jats:sup>\n                    <jats:sup>1<\/jats:sup>\n                    , with EO\u2010A generally exhibiting lower MICs than EO\u2010W. EO\u2010A was active against\n                    <jats:italic>Acinetobacter baumannii<\/jats:italic>\n                    ,\n                    <jats:italic>Candida krusei<\/jats:italic>\n                    , and\n                    <jats:italic>Candida parapsilosis<\/jats:italic>\n                    , whereas EO\u2010W showed no activity against these strains. Complementary in silico analyses supported these findings: PASS predictions suggested potential antibacterial and antifungal activity for the major constituents, and molecular docking indicated favorable binding of limonene and \u03b2\u2010bisabolene to DNA gyrase B (\n                    <jats:italic>A. baumannii<\/jats:italic>\n                    ) and lanosterol 14\u03b1\u2010demethylase (CYP51,\n                    <jats:italic>C. albicans<\/jats:italic>\n                    ), providing a mechanistic rationale for the observed antimicrobial effects. These results highlight the importance of seasonal collection in optimizing the bioactive potential of\n                    <jats:italic>D. lanceolata<\/jats:italic>\n                    leaves.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202503280","type":"journal-article","created":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T02:25:16Z","timestamp":1772763916000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["GNPS Untargeted GC\u2010MS Metabolomic Analysis of Essential Oils From\n                    <i>Duguetia lanceolata<\/i>\n                    and Evaluation of Antimicrobial Activity"],"prefix":"10.1002","volume":"23","author":[{"given":"Jackson","family":"Monteiro","sequence":"first","affiliation":[{"name":"Instituto De Ci\u00eancias Ambientais, Qu\u00edmicas e Farmac\u00eauticas Universidade Federal de S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geovanna N.","family":"Antonelli","sequence":"additional","affiliation":[{"name":"Instituto De Ci\u00eancias Ambientais, Qu\u00edmicas e Farmac\u00eauticas Universidade Federal de S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erick P.","family":"Dantas","sequence":"additional","affiliation":[{"name":"Instituto De Ci\u00eancias Ambientais, Qu\u00edmicas e Farmac\u00eauticas Universidade Federal de S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simone S.","family":"Grecco","sequence":"additional","affiliation":[{"name":"Instituto De Ci\u00eancias Ambientais, Qu\u00edmicas e Farmac\u00eauticas Universidade Federal de S\u00e3o Paulo  S\u00e3o Paulo Brazil"},{"name":"Instituto Paulista de Resist\u00eancia aos Antimicrobianos \u2010 ARIES (CEPID FAPESP), Escola Paulista De Medicina \u2013 EPM UNIFESP  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marisi G.","family":"Soares","sequence":"additional","affiliation":[{"name":"Instituto De Qu\u00edmica Universidade Federal de Alfenas  Alfenas Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u00e3o Henrique G.","family":"Lago","sequence":"additional","affiliation":[{"name":"Centro De Ci\u00eancias Naturais e Humanas Universidade Federal do ABC  Santo Andr\u00e9 Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renata C.","family":"Pascon","sequence":"additional","affiliation":[{"name":"Instituto De Ci\u00eancias Ambientais, Qu\u00edmicas e Farmac\u00eauticas Universidade Federal de S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcelo A.","family":"Vallim","sequence":"additional","affiliation":[{"name":"Instituto De Ci\u00eancias Ambientais, Qu\u00edmicas e Farmac\u00eauticas Universidade Federal de S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia","family":"Sartorelli","sequence":"additional","affiliation":[{"name":"Instituto De Ci\u00eancias Ambientais, Qu\u00edmicas e Farmac\u00eauticas Universidade Federal de S\u00e3o Paulo  S\u00e3o Paulo Brazil"},{"name":"Instituto Paulista de Resist\u00eancia aos Antimicrobianos \u2010 ARIES (CEPID FAPESP), Escola Paulista De Medicina \u2013 EPM UNIFESP  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,25]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.giec.2020.06.004"},{"key":"e_1_2_9_3_1","unstructured":"World Health Organization Antimicrobial\u2010Resistance(WHO 2023) accessed September 18 https:\/\/www.who.int\/news\u2010room\/fact\u2010sheets\/detail\/antimicrobial\u2010resistance."},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijheh.2022.114006"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jnatprod.9b01285"},{"key":"e_1_2_9_6_1","volume-title":"Handbook of Experimental Pharmacology","author":"\u00c1lvarez\u2010Mart\u00ednez F. 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